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Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 107 ()

The dysregulation of tryptophan-kynurenine pathway (TKP) is extensively involved in the pathophysiology of Alzheimer's disease, depression, and neurod......

Fetal brain vulnerability to SARS-CoV-2 infection

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 112 ()

Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RN......

132-adrenergic signaling promotes higher-affinity B cells and antibodies

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 113 ()

Stress-induced 132-adrenergic receptor (132AR) activation in B cells increases IgG secretion; however, the impact of this activation on antibody affin......

A novel role for astrocytic fragmented mitochondria in regulating morphine addiction

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 113 ()

Chronic morphine exposure causes the development of addictive behaviors, accompanied by an increase in neuroinflammation in the central nervous system......

Social relationships and epigenetic aging in older adulthood: Results from the Health and Retirement Study

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 114 ()

Growing evidence suggests that social relationship quality can influence age -related health outcomes, although how the quality of one's relationships......

Partner relationship quality and IL-6:IL-10 trajectories from pregnancy to a year after-birth

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 114 ()

Background: Inflammatory activity during pregnancy and the postpartum period shifts systematically due to pregnancy progression, delivery, and postpar......

High unrecognized SARS-CoV-2 exposure of newly admitted and hospitalized psychiatric patients

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 114 ()

Background: Patients with pre-existing mental disorders are at higher risk for SARS-CoV-2 infection and adverse outcomes, and severe mental illness, i......

Life stressors and immune aging: Protective effects of cognitive reappraisal

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 110 ()

Stressful life events may accelerate aspects of immune aging, but habitual use of an adaptive emotion regulation strategy, cognitive reappraisal, may ......

Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 110 ()

Remodeling of synapses by microglia is essential for synaptic plasticity in the brain. However, during neuro-inflammation and neurodegenerative diseas......

Reduction in GABAB on glia induce Alzheimer?s disease related changes

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 110 ()

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques (A beta), neuro-fibrillary tangles (NFT), and neuroinfl......

Microbial metabolites regulate social novelty via CaMKII neurons in the BNST

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 113 ()

Social novelty is a cognitive process that is essential for animals to interact strategically with conspecifics based on their prior experiences. The ......

Delayed cognitive impairments in a rat model of Gulf War Illness are stimulus-dependent

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 113 ()

Gulf War Illness (GWI) collectively describes the multitude of central and peripheral disturbances affecting soldiers who served in the 1990-1991 Gulf......

Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2023; 113 ()

Metabolomics, proteomics and DNA methylome assays, when done in tandem from the same blood sample and analyzed together, offer an opportunity to evalu......

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