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Epigenetic Age Acceleration Was Delayed in Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (3)

Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an acc......

Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

Recent large-scale integrative analyses (including Transcriptome-Wide Association Study [TWAS] and Summary-data-based Mendelian Randomization [SMR]) h......

Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (4)

Reduced cortical gray matter integrity and cognitive abilities are among core deficits in schizophrenia. We hypothesized that higher allostatic load (......

Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (3)

Schizophrenia is a complex psychiatric disorder exhibiting alterations in spontaneous and task-related cerebral activity whose relation (termed "state......

Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (1)

Minor neurological signs are subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts present in excess in the......

Metabolomic Identification of Exosome-Derived Biomarkers for Schizophrenia: A Large Multicenter Study

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (3)

Exosomes have been suggested as promising targets for the diagnosis and treatment of neurological diseases, including schizophrenia (SCZ), but the pot......

N-methyl-D-aspartate Receptor Antibody and White Matter Deficits in Schizophrenia Treatment-Resistance

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

Insufficient or lack of response to antipsychotic medications in some patients with schizophrenia is a major challenge in psychiatry, but the underlyi......

Neurological Soft Signs Are Associated With Altered Cerebellar-Cerebral Functional Connectivity in Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

Cerebellar dysfunction is associated with neurological soft signs (NSS), which is a promising endophenotype for schizophrenia spectrum disorders. Howe......

The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (1)

Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) a......

Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show signific......

Exosome Transplantation From Patients With Schizophrenia Causes Schizophrenia-Relevant Behaviors in Mice: An Integrative Multi-omics Data Analysis

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of exosomes in schizophrenia (SCZ) is unclear. Here, we demons......

Reduced Hippocampal Volume and Its Relationship With Verbal Memory and Negative Symptoms in Treatment-Naive First-Episode Adolescent-Onset Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (1)

Accumulating neuroimaging evidence has shown remarkable volume reductions in the hippocampi of patients with schizophrenia. However, the relationship ......

Disrupted Intersubject Variability Architecture in Functional Connectomes in Schizophrenia

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (3)

Schizophrenia (SCZ) is a highly heterogeneous disorder with remarkable intersubject variability in clinical presentations. Previous neuroimaging studi......

Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach

期刊: SCHIZOPHRENIA BULLETIN, 2021; 47 (5)

The results generated from large psychiatric genomic consortia show us some new vantage points to understand the pathophysiology of psychiatric disord......

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