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Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 414 (1)

ICER is a transcriptional repressor that is mono-or poly-ubiquitinated. This either causes ICER to be translocated from the nucleus, or degraded via t......

JIF:3.547

LncRNA HOTAIR promotes ?-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson?s disease

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 417 (1)

Parkinson's disease (PD) is a common neurodegenerative disease. Here, the purpose of the study was to explore the function of long non-coding RNA (lnc......

JIF:3.547

SIRT3-mediated deacetylation protects inner hair cell synapses in a H2O2-induced oxidative stress model in vitro

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (2)

Oxidative stress is considered a driving event in the damage to inner hair cell (IHC) synapses. Mitochondrial deacetylase sirtuin 3 (SIRT3) is an impo......

JIF:3.547

CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (1)

Cholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol hom......

JIF:3.547

Sorting nexins as a promising therapeutic target for cardiovascular disorders: An updated overview

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (1)

Sorting nexins (SNXs) are involved in sorting the protein cargo within the endolysosomal system. Recently, several studies have shown the role of SNXs......

JIF:3.547

Periodontal ligament fibroblasts-derived exosomes induced by PGE(2) inhibit human periodontal ligament stem cells osteogenic differentiation via activating miR-34c-5p/SATB2/ERK

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 419 (2)

Several studies have confirmed that exosomes containing microRNAs (miRNAs) from the aseptic inflammatory microenvironment play an important role in bo......

JIF:3.547

FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 420 (1)

Oxidative stress damage to the lens is a key factor in most cataracts. Forkhead box O 4 (FOXO4), a member of the forkhead box O family, plays a pivota......

JIF:3.547

Delineation of gastric tumors with activated ERK/MAPK signaling cascades for the development of targeted therapeutics

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 410 (1)

The ERK/MAPK signaling pathway is activated in various cancers including gastric cancer. Targeting the ERK/ MAPK/MEK pathway has been considered as a ......

JIF:3.547

Semaphorin 3E promote Schwann cell proliferation and migration

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 412 (2)

Schwann cells (SCs) play a critical role in peripheral nerve (PN) regeneration because of their ability to proliferate, migrate, and provide trophic s......

JIF:3.547

Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 413 (2)

Signal transducer and activator of transcription 3 (STAT3) plays key roles in cancer cell proliferation, invasion, and immunosuppression. In many huma......

JIF:3.547

Silencing of circ-CDK14 suppresses osteosarcoma progression through the miR-198/E2F2 axis

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 414 (1)

Background: Osteosarcoma (OS) is the most common primary bone malignancy. Circular RNAs (circRNAs) have been implicated in OS pathogenesis. In the cur......

JIF:3.547

Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 415 (2)

Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme that regulates serine/glycine transition; however, its specific function and molecular mecha......

JIF:3.547

Prognostic and therapeutic significance of XPO1 in T-cell lymphoma

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 416 (2)

T-cell lymphoma (TCL) is a highly heterogeneous group of invasive non-Hodgkin lymphoma with adverse prognosis and limited treatment options. The relat......

JIF:3.547

Activin A downregulates the CD69-MT2A axis via p38MAPK to induce erythroid differentiation that sensitizes BCR-ABL-positive cells to imatinib

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 417 (2)

Induction of differentiation sensitizes chronic myeloid leukemia (CML) cells to the BCR-ABL inhibitor imatinib by mechanisms that remain unknown. We p......

JIF:3.547

Identification of a long noncoding RNA Gm17501 as a novel negative regulator of cardiac hypertrophy

期刊: EXPERIMENTAL CELL RESEARCH, 2022; 418 (1)

Pathological cardiac hypertrophy is an independent risk factor for the development of heart failure. Long noncoding RNAs (lncRNAs), an emerging class ......

JIF:3.547

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