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Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (14)

Chromosome segregation requires assembly of the macromolecular kinetochore complex onto centromeric DNA. While most eukaryotes have canonical kinetoch......

JIF:3.531

Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (14)

Matrix stiffness and dimensionality have been shown to be major determinants of cell behavior. However, a workflow for examining nanometer-scale respo......

JIF:3.531

Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (2)

Positioning organelles at the right place and time is critical for their function and inheritance. In budding yeast, mitochondrial and nuclear positio......

JIF:3.531

Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (4)

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (BAIAP2L2), a membrane-binding protein required for the maintenance of mec......

JIF:3.531

Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (8)

Accumulating evidence indicates that mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases. Both of these conditions......

JIF:3.531

Atypical and distinct microtubule radial symmetries in the centriole and the axoneme of Lecudina tuzetae

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (8)

The centriole is a minute cylindrical organelle present in a wide range of eukaryotic species. Most centrioles have a signature ninefold radial symmet......

JIF:3.531

Ultrastructure of COPII vesicle formation in yeast characterized by correlative light and electron microscopy

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (13)

Traffic of proteins out of the endoplasmic reticulum (ER) is driven by the COPII coat, a layered protein scaffold that mediates the capture of cargo p......

JIF:3.531

Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (14)

Several studies have suggested a role for the LEM-domain protein emerin and the DNA binding factor BAF in nuclear envelope reformation after mitosis, ......

JIF:3.531

Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (14)

Pkd2 is the fission yeast homologue of polycystins. This putative ion channel localizes to the plasma membrane. It is required for the expansion of ce......

JIF:3.531

Membrane fusion by Drosophila atlastin does not require GTP hydrolysis

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (14)

Atlastin (ATL) GTPases undergo trans dimerization and a power strokelike crossover conformational rearrangement to drive endoplasmic reticulum membran......

JIF:3.531

Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (1)

Class III myosins are actin-based motors proposed to transport cargo to the distal tips of stereocilia in the inner ear hair cells and/or to participa......

JIF:3.531

The Rabl chromosome configuration masks a kinetochore reassembly mechanism in yeast mitosis

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (5)

During cell cycle progression in metazoans, the kinetochore is assembled at mitotic onset and disassembled during mitotic exit. Once assembled, the ki......

JIF:3.531

Counting fluorescently labeled proteins in tissues in the spinning-disk microscope using single-molecule calibrations

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (6)

Quantification of molecular numbers and concentrations in living cells is critical for testing models of complex biological phenomena. Counting molecu......

JIF:3.531

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (8)

Chromosome structure and nuclear organization are important factors in the regulation of gene expression. Transcription of a gene is influenced by loc......

JIF:3.531

Nucleotide- and Protein-Dependent Functions of Actg1

期刊: MOLECULAR BIOLOGY OF THE CELL, 2022; 33 (9)

Cytoplasmic beta- and gamma-actin proteins are 99% identical but support unique organismal functions. The cytoplasmic actin nucleotide sequences Actb ......

JIF:3.531

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