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Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model

期刊: CANCER LETTERS, 2023; 562 ()

Glioblastoma (GB) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mai......

Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice

期刊: CANCER LETTERS, 2023; 562 ()

Obesity has been linked to a higher risk of pancreatic cancer. However, the mechanism by which obesity promote pancreatic carcinogenesis is still uncl......

DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer

期刊: CANCER LETTERS, 2023; 568 ()

Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic tumor microenvironment (TME), which aids tumor progression, drug resistance, and i......

Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo

期刊: CANCER LETTERS, 2023; 574 ()

Pleural mesothelioma (PM) is characterized by poor prognosis and limited therapeutic options. Y-box-binding protein 1 (YB-1) was shown to drive growth......

Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors

期刊: CANCER LETTERS, 2023; 559 ()

The fibrinolytic system is involved in many physiological functions, among which the important members can interact with each other, either synergisti......

The diverse pancreatic tumor cell-intrinsic response to IFN? is determined by epigenetic heterogeneity

期刊: CANCER LETTERS, 2023; 562 ()

IFN gamma signaling is mainly mediated through the activation of the canonical JAK-STAT signaling pathway, tran-scription factors, and epigenetic modi......

AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations

期刊: CANCER LETTERS, 2023; 566 ()

HCC remains one of the most prevalent and deadliest cancers. Serum AFP level is a biomarker for clinical diagnosis of HCC, instead the contribution of......

Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer

期刊: CANCER LETTERS, 2023; 566 ()

Castration-resistant prostate cancer (CRPC) responds poorly to existing therapy and appears as the lethal consequence of prostate cancer (PCa) progres......

Disruption in networking of KCMF1 linked ubiquitin ligase impairs autophagy in CD8+memory T cells of patients with renal cell carcinoma

期刊: CANCER LETTERS, 2023; 564 ()

Metastatic Renal Cell Carcinoma (mRCC) remains incurable, despite the current checkpoint-blockade-driven, limited overall response rate. The CD8+ memo......

A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo

期刊: CANCER LETTERS, 2023; 565 ()

Small-molecule EGFR inhibitors have distinctly improved the overall survival especially in EGFR-mutated lung cancer. However, their use is often limit......

O-GlcNAcylation in cancer development and immunotherapy*

期刊: CANCER LETTERS, 2023; 566 ()

O-linked & beta;-D-N-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is a reversible reaction that attaches & beta;-N......

Lipid metabolism reprogramming of CD8+T cell and therapeutic implications in cancer

期刊: CANCER LETTERS, 2023; 567 ()

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor microenvironment (TME), metabolism dysfunction of the three should take ......

Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

期刊: CANCER LETTERS, 2023; 570 ()

Cancer poses a significant global health burden, necessitating the widespread use of chemotherapy and radiotherapy as conventional frontline intervent......

LIMK1 m6A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation

期刊: CANCER LETTERS, 2023; 576 ()

LIM kinase 1 (LIMK1) is a member of the LIMK family that has been considered to be involved in chemoresistance in various tumors, and N6-methyladenosi......

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