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Intestinal Ultrasound for Differentiating Fibrotic or Inflammatory Stenosis in Crohn's Disease: A Systematic Review and Meta-analysis

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (9)

Background and Aims Intestinal ultrasound [IUS] has been increasingly reported to distinguish inflammatory or fibrotic intestinal stenosis in Crohn's ......

JIF:7.617

Mesenteric Adipose Tissue Contributes to Intestinal Fibrosis in Crohn's Disease Through the ATX-LPA Axis

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (7)

Background and Aims Intestinal fibrostenosis is an important cause of surgical intervention in patients with Crohn's disease [CD]. Hypertrophic mesent......

JIF:7.617

Gut Epithelial-derived CXCL9 Maintains Gut Homeostasis Through Preventing Overgrown E. coli

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (6)

Background and Aims Increased E. coli in the colon are related to the occurrence and development of multiple diseases. Chemokines are shown to possess......

JIF:7.617

The Development and Validation of Anti-paratuberculosis-nocardia Polypeptide Antibody [Anti-pTNP] for the Diagnosis of Crohn's Disease

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (7)

Background and Aims Non-invasive biomarkers in sera of patients with inflammatory bowel disease [IBD] are not currently available for rapidly and accu......

JIF:7.617

MiR-1-3p and MiR-124-3p Synergistically Damage the Intestinal Barrier in the Ageing Colon

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (4)

Background and Aims Disruption of the intestinal barrier of the digestive tract is a common pathophysiological change in the elderly, which may partly......

JIF:7.617

Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (7)

Background and Aims Regulation of macrophage polarization is a promising strategy for treating inflammatory bowel disease [IBD]. Tollip is an importan......

JIF:7.617

Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (8)

Background and Aims Group 3 innate lymphoid cells [ILC3s] sense environmental signals and are critical in gut homeostasis and immune defence. G-protei......

JIF:7.617

Aberrant Mesenteric Adipose Extracellular Matrix Remodelling is Involved in Adipocyte Dysfunction in Crohn's Disease: The Role of TLR-4-mediated Macrophages

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (11)

Background and Aims Hypertrophic mesenteric adipose tissue [htMAT] is involved in the disease progression of Crohn's disease [CD] through expressing p......

JIF:7.617

An IRF1-dependent Pathway of TNF alpha-induced Shedding in Intestinal Epithelial Cells

期刊: JOURNAL OF CROHNS & COLITIS, 2022; 16 (1)

Background Shedding of intestinal epithelial cells [IECs] is a potent cause of barrier loss which plays an important role in the pathogenesis of infla......

JIF:7.617

ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease

期刊: JOURNAL OF CROHNS & COLITIS, 2021; 15 (1)

Background and Aims: There is evidence for a disturbed necroptosis function in many inflammatory diseases, but its role in inflammatory bowel diseases......

M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/beta-Catenin Signalling Axis

期刊: JOURNAL OF CROHNS & COLITIS, 2021; 15 (4)

Background and Aims: M2 phenotype macrophages are involved in the resolution of inflammation and intestinal repair. Exosomes are emerging as important......

miR-130a-3p, a Preclinical Therapeutic Target for Crohn's Disease

期刊: JOURNAL OF CROHNS & COLITIS, 2021; 15 (4)

Background: Crohn's disease [CD] is a chronic, relapsing and incurable inflammatory disorder. Micro RNAs [miRNAs], which modulate gene expression by b......

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