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Safety and pharmacokinetics of a new biosimilar trastuzumab (HL02): a Phase I bioequivalence study in healthy Chinese men

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2022; 22 (2)

Objectives: The study aimed to explore the bioequivalence of a proposed biosimilar HL02 vs. its reference products (US-trastuzumab) among healthy Chin......

JIF:3.628

Envafolimab - first PD-1/PD-L1 antibody to be administered by subcutaneous injection for microsatellite instability-high or deficient mismatch repair advanced solid tumors

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2022; 22 (10)

Introduction Programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors mobilize and activate the anti-tumor activity of the immune system b......

JIF:3.628

Symbiotic microorganisms: prospects for treating atopic dermatitis

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2022; 22 (7)

Introduction Atopic dermatitis (AD) is a common chronic recurrent inflammatory skin disease. The pathogenesis is unclear but may be related to genetic......

JIF:3.628

Pharmacokinetic bioequivalence, safety, and immunogenicity of GB222, a bevacizumab biosimilar candidate, and bevacizumab in Chinese healthy males: a randomized clinical trial

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2022; 22 (2)

Background This study was conducted to compare the similarity of the pharmacokinetics (PKs), safety, and immunogenicity of GB222, a potential bevacizu......

JIF:3.628

Prospects of cell chemotactic factors in bone and cartilage tissue engineering

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2022; 22 (7)

Introduction Tissue engineering has brought hope for the repair of bone and cartilage injury. As potential therapeutic molecules for use in tissue eng......

JIF:3.628

Safety and pharmacokinetics of a new biosimilar trastuzumab (HL02): a Phase I bioequivalence study in healthy Chinese men

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, ; ()

Objectives: The study aimed to explore the bioequivalence of a proposed biosimilar HL02 vs. its reference products (US-trastuzumab) among healthy Chin......

Merits of the 'good' viruses: the potential of virus-based therapeutics

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, ; ()

Introduction: Although viruses have generally been considered as pathogens ever since their discovery, recent research has revealed that they might as......

Prognostic clinical factors in patients affected by non-small-cell lung cancer receiving Nivolumab

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2020; 20 (3)

Background: Immune-checkpoint inhibitors have radically changed the treatment landscape of Non-Small-Cell Lung Cancer (NSCLC). It is still unclear whe......

DC-CIK as a widely applicable cancer immunotherapy

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2020; 20 (6)

Introduction: Immunotherapy is now a standard treatment for many malignancies. Although immune checkpoint inhibition has demonstrated substantial effi......

Promising RNA-based cancer gene therapy using extracellular vesicles for drug delivery

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2020; 20 (7)

Introduction: RNA-based cancer gene therapy shows potential in cancer treatment. However, the safe and efficient transfer of therapeutic RNA to target......

Toripalimab for the treatment of melanoma

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2020; 20 (8)

Introduction: Immune therapies have dramatically changed the treatment landscape for melanoma in the past decade. Ipilimumab, nivolumab, and pembroliz......

CAR-T cells: the Chinese experience

期刊: EXPERT OPINION ON BIOLOGICAL THERAPY, 2020; 20 (11)

Introduction Chimeric antigen receptor T (CAR-T) cells are harnessed to identify and lyse malignant cells specifically, efficiently, and independently......

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