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Integrin alpha 6 overexpression promotes lymphangiogenesis and lymphatic metastasis via activating the NF-kappa B signaling pathway in lung adenocarcinoma

期刊: CELLULAR ONCOLOGY, 2022; 45 (1)

Objective It has been reported that tumor-associated lymphangiogenesis plays an important role in lymph node metastasis and contributes to the poor su......

JIF:6.174

The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth

期刊: CELLULAR ONCOLOGY, 2022; 45 (6)

Background CXCL11 has been reported to be up-regulated in hepatocellular carcinoma (HCC) tissues and cancer-associated fibroblasts (CAFs), and CAF-sec......

JIF:6.174

Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma

期刊: CELLULAR ONCOLOGY, 2022; 45 (1)

Background Hippocalcin-like 1 (HPCAL1), a neuronal calcium sensor protein family member, has been reported to regulate cancer growth. As yet, however,......

JIF:6.174

Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer

期刊: CELLULAR ONCOLOGY, 2022; 45 (2)

Pancreatic ductal metaplasia (PDM) is the transformation of potentially various types of cells in the pancreas into ductal or ductal-like cells, which......

JIF:6.174

Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer

期刊: CELLULAR ONCOLOGY, 2022; 45 (5)

Purpose We aimed to elucidate the applicability of tumor organoids for inherent drug resistance of primary liver cancer (PLC) and mechanisms of acquir......

JIF:6.174

Spheroid-induced heterogeneity and plasticity of uveal melanoma cells

期刊: CELLULAR ONCOLOGY, 2022; 45 (2)

Purpose The mechanism underlying cancer heterogeneity and plasticity remains elusive, in spite of the fact that multiple hypotheses have been put forw......

JIF:6.174

SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans

期刊: CELLULAR ONCOLOGY, 2022; 45 (3)

Background Solute carrier family 26 member (SLC26A9) is a Cl- uniporter with very high expression levels in the gastric mucosa. Here, we describe morp......

JIF:6.174

GAS41 mediates proliferation and GEM chemoresistance via H2AZ2 and Notch1 in pancreatic cancer

期刊: CELLULAR ONCOLOGY, 2022; 45 (3)

Purpose GAS41 is a YEATS domain protein that binds to acetylated histone H3 to promote the chromatin deposition of H2A.Z in non-small cell lung cancer......

JIF:6.174

A m(6)A methyltransferase-mediated immune signature determines prognosis, immune landscape and immunotherapy efficacy in patients with lung adenocarcinoma

期刊: CELLULAR ONCOLOGY, 2022; 45 (5)

Background As the most abundant modification in mRNA, the N-6-methyladenosine (m(6)A) RNA modification is involved in the occurrence and development o......

JIF:6.174

A comprehensive review of SHP2 and its role in cancer

期刊: CELLULAR ONCOLOGY, 2022; 45 (5)

Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase ubiquitously expressed mainly in the cy......

JIF:6.174

FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer

期刊: CELLULAR ONCOLOGY, 2022; 45 (2)

Background Phosphohistidine phosphatase 1 (PHPT1) is an oncogene that has been reported to participate in multiple tumorigenic processes. As yet, howe......

JIF:6.174

SPOCK1 promotes metastasis in pancreatic cancer via NF-kappa B-dependent epithelial-mesenchymal transition by interacting with I kappa B-alpha

期刊: CELLULAR ONCOLOGY, 2022; 45 (1)

Background Sparc/osteonectin, cwcv and kazal-like domain proteoglycan 1 (SPOCK1) has been reported to function as an oncogene in a variety of cancer t......

JIF:6.174

Applications and mechanisms of the cyclin-dependent kinase 4/6 inhibitor, PD-0332991, in solid tumors

期刊: CELLULAR ONCOLOGY, 2022; 45 (6)

Abnormal CDK4/6-Rb-E2F signal transduction is a common finding in tumors and is a driving factor for the excessive proliferation of various tumor cell......

JIF:6.174

VHL and DNA damage repair pathway alterations as potential clinical biomarkers for first-line TKIs in metastatic clear cell renal cell carcinomas

期刊: CELLULAR ONCOLOGY, 2022; 45 (4)

Purpose Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) are being used for the first-line treatment of metastatic ......

JIF:6.174

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