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Propagated alpha-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice

期刊: BRAIN, 2020; 143 ()

Idiopathic rapid eye movement sleep behaviour disorder (RBD) is now recognized as an early manifestation of alpha-synucleinopathies. Increasing experi......

Resective epilepsy surgery in tuberous sclerosis complex: a nationwide multicentre retrospective study from China

期刊: BRAIN, 2020; 143 ()

At least 50% of patients with tuberous sclerosis complex present with intractable epilepsy; for these patients, resective surgery is a treatment optio......

Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/beta-catenin signalling

期刊: BRAIN, 2020; 143 ()

Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, found that MIR22HG, the host ......

Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification

期刊: BRAIN, 2020; 143 ()

Primary familial brain calcification is a monogenic disease characterized by bilateral calcifications in the basal ganglia and other brain regions, an......

Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia

期刊: BRAIN, 2020; 143 ()

Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of this dysconnectivity is unknown, but animal models imply dy......

White matter basis for the hub-and-spoke semantic representation: evidence from semantic dementia

期刊: BRAIN, 2020; 143 ()

The hub-and-spoke semantic representation theory posits that semantic knowledge is processed in a neural network, which contains an amodal hub, the se......

Prognosis for patients with cognitive motor dissociation identified by brain-computer interface

期刊: BRAIN, 2020; 143 ()

Cognitive motor dissociation describes a subset of patients with disorders of consciousness who show neuroimaging evidence of consciousness but no det......

In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse

期刊: BRAIN, 2020; 143 ()

Many RNA-binding proteins, including TDP-43, FUS, and TIA1, are stress granule components, dysfunction of which causes amyotrophic lateral sclerosis (......

Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities

期刊: BRAIN, 2020; 143 ()

The prognosis of intracerebral haemorrhage continues to be devastating despite much research into this condition. A prominent feature of intracerebral......

Two distinc neuroanatomica subtypes of schizophrenia revealed using machine learning

期刊: BRAIN, 2020; 143 ()

Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current analyses. We investigated neuroanatomical subtypes in a mult......

Microglial exosomes facilitate alpha-synuclein transmission in Parkinson's disease

期刊: BRAIN, 2020; 143 ()

Accumulation of neuronal alpha-synuclein is a prominent feature in Parkinson's disease. More recently, such abnormal protein aggregation has been repo......

Development and validation of an interpretable deep learning framework for Alzheimer's disease classification

期刊: BRAIN, 2020; 143 ()

Alzheimer's disease is the primary cause of dementia worldwide, with an increasing morbidity burden that may outstrip diagnosis and management capacit......

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