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Altered temporal, but intact spatial, features of transient network dynamics in psychosis

期刊: MOLECULAR PSYCHIATRY, ; ()

Contemporary models of psychosis suggest that a continuum of severity of psychotic symptoms exists, with subthreshold psychotic experiences (PEs) pote......

Bioenergetics and abnormal functional connectivity in psychotic disorders

期刊: MOLECULAR PSYCHIATRY, ; ()

Psychotic Disorders such as schizophrenia (SZ) and bipolar disorder (BD) are characterized by abnormal functional connectivity (FC) within neural netw......

Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity

期刊: MOLECULAR PSYCHIATRY, ; ()

Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to energy deficits and play a key role in the control of feeding be......

Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence

期刊: MOLECULAR PSYCHIATRY, ; ()

Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the pathogenesis of schizophrenia. Using in vivo two-photon......

The impact of quarantine on mental health status among general population in China during the COVID-19 pandemic

期刊: MOLECULAR PSYCHIATRY, ; ()

Quarantine and isolation measures urgently adopted to control the COVID-19 pandemic might potentially have negative psychological and social effects. ......

MAP2 is differentially phosphorylated in schizophrenia, altering its function

期刊: MOLECULAR PSYCHIATRY, ; ()

Schizophrenia (Sz) is a highly polygenic disorder, with common, rare, and structural variants each contributing only a small fraction of overall disea......

Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review

期刊: MOLECULAR PSYCHIATRY, ; ()

Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a si......

Dysbindin-1 regulates mitochondrial fission and gamma oscillations

期刊: MOLECULAR PSYCHIATRY, ; ()

Mitochondria are cellular ATP generators. They are dynamic structures undergoing fission and fusion. While much is known about the mitochondrial fissi......

Update on GPCR-based targets for the development of novel antidepressants

期刊: MOLECULAR PSYCHIATRY, ; ()

Traditional antidepressants largely interfere with monoaminergic transport or degradation systems, taking several weeks to have their therapeutic acti......

An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data

期刊: MOLECULAR PSYCHIATRY, ; ()

Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has been extensively described. Nevertheless, the alternative splicin......

WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGF beta signaling

期刊: MOLECULAR PSYCHIATRY, 2021; 26 (2)

Adult hippocampal neurogenesis, a process considered important for hippocampal function, is regulated at multiple molecular levels. Mutations in the g......

delta-Secretase-cleaved Tau stimulates A beta production via upregulating STAT1-BACE1 signaling in Alzheimer's disease

期刊: MOLECULAR PSYCHIATRY, 2021; 26 (2)

delta-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neu......

Reduced motor cortex GABA(B)R function following chronic alcohol exposure

期刊: MOLECULAR PSYCHIATRY, 2021; 26 (2)

The GABA(B) receptor (GABA(B)R) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlyin......

Regulator of calcineurin 1 is a novel RNA-binding protein to regulate neuronal apoptosis

期刊: MOLECULAR PSYCHIATRY, 2021; 26 (4)

Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncod......

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