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Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (11)

The systemic biodistribution of endogenous extracellular vesicles is central to the maintenance of tissue homeostasis. Here, we show that angiogenesis......

A topical gel for extended ocular drug release

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (11)

The delivery of drugs to the eye can be prolonged via a gelling hypotonic solution that forms a clear thin layer on the eye's surface.

Adenine base editing in an adult mouse model of tyrosinaemia

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (1)

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse mo......

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (1)

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppresso......

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