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BECN2 (beclin 2)-mediated non-canonical autophagy in innate immune signaling and tumor development

期刊: AUTOPHAGY, 2020; 16 (12)

BECN2 (beclin 2) is a newly identified mammalian-specific macroautophagy/autophagy family member, and plays a critical role in the control of obesity ......

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

期刊: AUTOPHAGY, 2020; 16 (2)

A switch from autophagy to apoptosis is implicated in chondrocytes during the osteoarthritis (OA) progression with currently unknown mechanism(s). In ......

Autophagy induction by thiostrepton for the improvement of anticancer therapy

期刊: AUTOPHAGY, 2020; 16 (6)

Macroautophagy/autophagy induction by caloric restriction mimetics (CRMs) is a strategy to stimulate anticancer immune responses of immunogenic cell d......

The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway

期刊: AUTOPHAGY, 2020; 16 (1)

Damaged or redundant peroxisomes and their luminal cargoes are removed by pexophagy, a selective autophagy pathway. In yeasts, pexophagy depends mostl......

Emerging views of mitophagy in immunity and autoimmune diseases

期刊: AUTOPHAGY, 2020; 16 (1)

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating evidence implicates elimination ......

The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target

期刊: AUTOPHAGY, 2020; 16 (10)

Although macroautophagy/autophagy is involved in hepatocellular carcinoma (HCC) initiation and development and has been identified as a mechanism of H......

The protease activity of human ATG4B is regulated by reversible oxidative modification

期刊: AUTOPHAGY, 2020; 16 (10)

Macroautophagy/autophagy plays a pivotal role in cytoplasmic material recycling and metabolic turnover, in which ATG4B functions as a "scissor" for pr......

The bifunctional role of TP53INP2 in transcription and autophagy

期刊: AUTOPHAGY, 2020; 16 (7)

Cells integrate intracellular and extracellular cues to precisely control the balance of anabolic and catabolic processes, which is essential for cell......

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

期刊: AUTOPHAGY, 2020; 16 (11)

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells......

Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice

期刊: AUTOPHAGY, 2020; 16 (11)

Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroa......

Atg38-Atg8 interaction in fission yeast establishes a positive feedback loop to promote autophagy

期刊: AUTOPHAGY, 2020; 16 (11)

Macroautophagy (autophagy) is driven by the coordinated actions of core autophagy-related (Atg) proteins. Atg8, the core Atg protein generally conside......

Endothelial autophagy deficiency induces IL6-dependent endothelial mesenchymal transition and organ fibrosis

期刊: AUTOPHAGY, 2020; 16 (10)

Macroautophagy/autophagy plays a vital role in the homeostasis of diverse cell types. Vascular endothelial cells contribute to vascular health and pla......

A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells

期刊: AUTOPHAGY, 2020; 16 (12)

IFNL2 is a potent antiviral interferon, but the regulation of its gene expression is not fully clear. Here, we report the regulation of ATG10S for IFN......

Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells

期刊: AUTOPHAGY, 2020; 16 (12)

Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeu......

Autophagy-mediated compartmental cytoplasmic deletion is essential for tobacco pollen germination and male fertility

期刊: AUTOPHAGY, 2020; 16 (12)

In plants, macroautophagy/autophagy has mainly been associated with stress-related processes but how it impacts normal physiological and developmental......

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