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Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum

期刊: BIOLOGICAL PSYCHIATRY, 2021; 89 (11)

BACKGROUND: Takeda G protein-coupled receptor 5 (TGR5) is recognized as a promising target for type 2 diabetes and metabolic syndrome; its expression ......

Socioeconomic Deprivation Index Is Associated With Psychiatric Disorders: An Observational and Genome-wide Gene-by-Environment Interaction Analysis in the UK Biobank Cohort

期刊: BIOLOGICAL PSYCHIATRY, 2021; 89 (9)

BACKGROUND: Psychiatric disorders are among the largest and fastest-growing categories of the global disease burden. However, limited effort has been ......

Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits

期刊: BIOLOGICAL PSYCHIATRY, 2021; 89 (12)

BACKGROUND: The origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given establish......

Persistently Elevated mTOR Complex 1-S6 Kinase 1 Disrupts DARPP-32-Dependent D1 Dopamine Receptor Signaling and Behaviors

期刊: BIOLOGICAL PSYCHIATRY, 2021; 89 (11)

BACKGROUND: The serine-threonine kinase mTORC1 (mechanistic target of rapamycin complex 1) is essential for normal cell function but is aberrantly act......

Socioeconomic Disparities Affect Children's Amygdala-Prefrontal Circuitry via Stress Hormone Response

期刊: BIOLOGICAL PSYCHIATRY, 2021; 90 (3)

BACKGROUND: The socioeconomic status (SES) of a family can affect almost all aspects of a child's life, including health and current and future achiev......

Amygdala Circuit Substrates for Stress Adaptation and Adversity

期刊: BIOLOGICAL PSYCHIATRY, 2021; 89 (9)

Brain systems that promote maintenance of homeostasis in the face of stress have significant adaptive value. A growing body of work across species dem......

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