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A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (6)

Background: Group 2 innate lymphoid cells (ILC2s), the innate counterpart of TH2 cells, play a critical role in type 2 immune responses. However, the ......

JIF:6.218

Hsa_circ_0004287 inhibits macrophagemediated inflammation in an N-6-methyladenosine-dependent manner in atopic dermatitis and psoriasis

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (6)

Background: Circular RNA (circRNA) has been implicated in various diseases; however, its role in atopic dermatitis (AD) or psoriasis remains unclear. ......

JIF:6.218

Adapting to the world: The determination and plasticity of T follicular helper cells

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 150 (5)

Antibodies are crucial in host defenses as well as in allergic diseases. T follicular helper (T-FH) cells play essential roles in germinal center reac......

JIF:6.218

Extrafollicular PD-1(high)CXCR5(-)CD4(+) T cells participate in local immunoglobulin production in nasal polyps

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (2)

Background: Local immunoglobulin hyperproduction is observed in nasal polyps (NPs) with and without ectopic lymphoid tissues (eLTs). Objective: Our ai......

JIF:6.218

IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 150 (2)

Background: Pyroptosis is closely related to inflammation. However, the molecular mechanisms and pathologic contributions of pyroptotic epithelial cel......

JIF:6.218

Constituents of fine particulate matter and asthma in 6 low- and middle-income countries

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 150 (1)

Background: Evidence concerning the effects of different chemical components of particulate matter with an aerodynamic diameter of 2.5 mu m or less (P......

JIF:6.218

ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (4)

Background: Orosomucoid 1-like protein 3 (ORMDL3), a transmembrane protein localized in the endoplasmic reticulum (ER), has been genetically associate......

JIF:6.218

CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 150 (1)

Background: Circular RNAs (circRNAs) play potentially important roles in various human diseases; however, their roles in the goblet cell metaplasia of......

JIF:6.218

P17 induces chemotaxis and differentiation of monocytes via MRGPRX2-mediated mast cell-line activation

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (1)

Background: P17, a peptide isolated from Tetramorium bicarinatum ant venom, is known to induce an alternative phenotype of human monocyte-derived macr......

JIF:6.218

Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (4)

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic and contagious coronavirus that caused a global pandem......

JIF:6.218

Untargeted metabolomic profiling identifies disease-specific and outcome-related signatures in chronic rhinosinusitis

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 150 (3)

Background: Although metabolomics provides novel insights into disease mechanisms and biomarkers, the metabolic alterations in local tissues affected ......

JIF:6.218

CD38(+) B cells affect immunotherapy for allergic rhinitis

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022; 149 (5)

Background: Allergen-specific immunotherapy (AIT) is the mainstay in the treatment of allergic diseases, but the therapeutic effects of AIT need to be......

JIF:6.218

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021; 148 (2)

Background: Recognition of viral nucleic acids is one of the primary triggers for a type I interferon-mediated antiviral immune response. Inborn error......

Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study

期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021; 147 (5)

Background: Epidemiological data show that traffic-related air pollution contributes to the increasing prevalence and severity of asthma. DNA methylat......

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