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Identification of clinical and molecular features of recurrent serous borderline ovarian tumour

期刊: ECLINICALMEDICINE, 2022; 46 ()

Background Serous borderline ovarian tumour (SBOT) is the most common type of BOT. Fertility sparing surgery (FSS) is an option for patients with SBOT......

Reconstruction of paralyzed arm function in patients with hemiplegia through contralateral seventh cervical nerve cross transfer: a multicenter study and real-world practice guidance

期刊: ECLINICALMEDICINE, 2022; 43 ()

Background A previous randomized controlled trial showed contralateral seventh cervical nerve (CC7) cross transfer to be safe and effective in restori......

Malnutrition is positively associated with cognitive decline in centenarians and oldest-old adults: A cross-sectional study

期刊: ECLINICALMEDICINE, 2022; 47 ()

Background Cognitive decline is a growing public health concern. However, presently, only a few large-scale studies are available on the prevalence of......

Association of the depressive scores, depressive symptoms, and conversion patterns of depressive symptoms with the risk of new-onset chronic diseases and multimorbidity in the middle-aged and elderly Chinese population

期刊: ECLINICALMEDICINE, 2022; 52 ()

Background The relationship between depressive symptoms (DS) and their conversion patterns over time and the new-onset risk of diseases in the middle-......

Chronotype and cognitive function: Observational study and bidirectional Mendelian randomization

期刊: ECLINICALMEDICINE, 2022; 53 ()

Background Association has been found between chronotype and cognitive function in conventional observational studies but whether this association is ......

Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled phase 2 trial

期刊: ECLINICALMEDICINE, 2022; 54 ()

Background More effective vaccine candidates against variants of concern as a booster dose are needed in people primed with two-dose inactivated COVID......

Dynamic changes of pulmonary diffusion capacity in survivors of non-critical COVID-19 during the first six months

期刊: ECLINICALMEDICINE, 2022; 43 ()

Background The dynamic trends of pulmonary function in coronavirus disease 2019 (COVID-19) survivors since discharge have been rarely described. We ai......

Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study

期刊: ECLINICALMEDICINE, 2022; 53 ()

Background The existing dementia risk models are limited to known risk factors and traditional statistical methods. We aimed to employ machine learnin......

Risk of hepatitis B virus reactivation following treatment with abatacept: A retrospective study of international pharmacovigilance databases

期刊: ECLINICALMEDICINE, 2022; 48 ()

Background Abatacept is a selective T-cell costimulation modulator approved for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, ......

Safety and efficacy of mesenchymal stem cells in severe/critical patients with COVID-19: A systematic review and meta-analysis

期刊: ECLINICALMEDICINE, 2022; 51 ()

Background The present study aims to better understand the efficacy and safety of mesenchymal stromal cells (MSCs) in treating severe/critical patient......

Association of galactose and insulin resistance in polycystic ovary syndrome: A case-control study

期刊: ECLINICALMEDICINE, 2022; 47 ()

Background Polycystic ovary syndrome (PCOS) is closely linked to metabolic disorders. Recent reports have identified galactose as having strong associ......

Lethal diquat poisoning manifests as acute central nervous system injury and circulatory failure: A retrospective cohort study of 50 cases

期刊: ECLINICALMEDICINE, 2022; 52 ()

Background The mortality rate of patients with diquat (DQ) poisoning is extremely high due to insufficient understanding of DQ-induced injury. This st......

Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial

期刊: ECLINICALMEDICINE, 2022; 54 ()

Background Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist, achi......

Association of longitudinal changes in serum lipids with the natural history of subclinical hypothyroidism: A retrospective cohort study using data from the REACTION study

期刊: ECLINICALMEDICINE, 2022; 53 ()

Background Subclinical hypothyroidism (SCH) often leads to alterations in lipid profile, which may negatively impact humans health. Whether lipids in ......

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