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UHPLC-MS/MS method for chiral separation of 3-hydroxy fatty acids on amylose-based chiral stationary phase and its application for the enantioselective analysis in plasma and platelets

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 223 ()

3-Hydroxyfatty acids (3-OH-FAs) are formed in the hydration step during mitochondrial beta-oxidation of saturated straight-chain fatty acids, which is......

A three-dimensional integration strategy for Q-markers identification: Taken Euphorbia Pekinensis Radix as an example

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 224 ()

Euphorbia Pekinensis Radix (EPR) is an important antitumor medicinal resource. However, quality control of EPR has not been well established due to th......

Chiral LC-MS/MS method for the simultaneous determination of (R, S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 224 ()

A convenient LC-MS/MS assay method to simultaneously and sensitively determine (R,S)-ketamine (Ket), (R,S)-norketamine (NK), and (2R,6R;2S,6S)-hydroxy......

Characterization of Calculus bovis by principal component analysis assisted qHNMR profiling to distinguish nefarious frauds

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 228 ()

A new approach is developed for the reliable classification of Calculus bovis along with the identification of willfully contaminated C. bovis species......

Determination of cannabinoids in human cerumen samples by use of UPLC-MS/MS as a potential biomarker for drug use

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 231 ()

A quantitative analytical procedure was developed and validated by the use of Ultra- Performance Liquid Chromatography tandem Mass Spectrometry (UPLC-......

Simultaneous determination of 24 antiepileptic drugs and their active metabolites in human plasma by UHPLC-MS/MS

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 232 ()

Antiepileptic drugs (AEDs) have narrow therapeutic ranges with large individual variability. Routine therapeutic drug monitoring of AEDs was useful fo......

Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 232 ()

Gynostemma pentaphyllum (Thunb.) Makino is an herbaceous plant of Cucurbitaceae family, which has been widely used as an herbal tea and traditional Ch......

Liquid chromatography - tandem mass spectrometry method for determination of natalizumab in serum and cerebrospinal fluid of patients with multiple sclerosis

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 234 ()

Natalizumab is a humanized recombinant monoclonal IgG4 antibody used in the treatment of multiple sclerosis. Commonly used methods for natalizumab and......

Post-translational modifications comparative identification and kinetic study of infliximab innovator and biosimilars in serum using capillary electrophoresis-tandem mass spectrometry

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 234 ()

Despite reports indicating the potential impact of post-translational modifications on the activity of a monoclonal antibody, their prediction or moni......

Effects of (20 R)-Panaxadiol on NAFLD using non-targeted metabolomics in stool

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 234 ()

Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by hepatocyte steatosis and adipose accumulation with the main lesion i......

Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 235 ()

Alzheimer's disease (AD) is a progressive disease with continuous brain changes and has caused a severe burden on families and society. Huanglian Jied......

An amperometric method for the determination of cystine in urine samples and pharmaceutical tablets using screen-printed silver electrodes

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 235 ()

Elevated urinary cystine levels are closely associated with the development of cystine stone. Therefore, the ability to rapidly and efficiently determ......

Enantioselective in vitro metabolism of the herbicide diclofop-methyl: Prediction of toxicokinetic parameters and reaction phenotyping

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 235 ()

Human exposure to contaminants of emerging concern, like pesticides, has increased in the past decades. Diclofop-methyl (DFM) is a chiral herbicide th......

Fuzi decoction treats chronic heart failure by regulating the gut microbiota, increasing the short-chain fatty acid levels and improving metabolic disorders

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 236 ()

Fuzi decoction (FZD) is clinically used to treat chronic heart failure (CHF) in China, but the mechanism underlying FZD treatment in CHF remains uncle......

Deep eutectic solvents combined with beta-cyclodextrin derivatives for chiral separation of typical adrenergic receptor agonists by capillary electrophoresis with amperometric detection

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023; 236 ()

Enantioseparation has always been one of the research hotspots and difficulties in the field of modern separation science. In this work, a binary chir......

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