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Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (4)

Circadian rhythm disorder is a significant risk factor for mental diseases, and the recovery of circadian rhythm function has gradually become a signa......

JIF:11.694

Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 72 (2)

Melatonin is widely involved in plant disease resistance through modulation of immune responses. Pathogenesis-related (PR) proteins play important rol......

JIF:11.694

The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 72 (4)

Melatonin is known to involve multiple physiological actions in plants. Herein, we found that exogenous melatonin inhibited the Arabidopsis seedling g......

JIF:11.694

Melatonin alleviates PM2.5-induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (4)

Exposure to fine particulate matter (PM2.5) was associated with an increased incidence of liver metabolic disease. Melatonin has been shown to prevent......

JIF:11.694

Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (2)

Recent evidence indicates that the mitochondrial functions of chondrocytes are impaired in the pathogenesis of osteoarthritis (OA). Melatonin can atte......

JIF:11.694

Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR-135b-3p/TOX3 axis

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (2)

Melatonin is a hormone synthesized in the pineal gland and has widespread physiological and pharmacological functions. Moreover, it can activate prote......

JIF:11.694

Melatonin improves cardiac remodeling and brain-heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (4)

Light in the external environment might affect cardiovascular function. The light disruption seems to be related to changes in cardiovascular physiolo......

JIF:11.694

Melatonin delays dark-induced leaf senescence by inducing miR171b expression in tomato

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 72 (3)

Melatonin functions in multiple aspects of plant growth, development, and stress response. Nonetheless, the mechanism of melatonin in plant carbon met......

JIF:11.694

Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 72 (1)

Increasing evidence suggests that in vitro fertilization (IVF) may be associated with an increased risk of developing obesity and metabolic diseases l......

JIF:11.694

Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (2)

Aflatoxin B1 (AFB1) is a widespread contaminant in foods and feedstuffs, and its target organ is the liver. Melatonin (MT) has been shown to alleviate......

JIF:11.694

Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (2)

Melatonin (MT) functions in removing reactive oxygen species (ROS) and delaying plant senescence, thereby acting as an antioxidant; however, the molec......

JIF:11.694

Single-cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug-resistance in lung adenocarcinoma

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (1)

Circadian rhythm disruption (CRD) represents a major contributor to tumor proliferation. Nonetheless, the role of CRD in the clinical prediction of ca......

JIF:11.694

Melatonin alleviates the heat stress-induced impairment of Sertoli cells by reprogramming glucose metabolism

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 73 (3)

Sertoli cells (SCs) provide structural and nutritional support for developing germ cells. Normal glucose metabolism of SCs is necessary for spermatoge......

JIF:11.694

Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin alpha(2)beta(1) expression

期刊: JOURNAL OF PINEAL RESEARCH, 2022; 72 (3)

Advanced prostate cancer often develops into bone metastasis, which is characterized by aberrant bone formation with chronic pain and lower chances of......

JIF:11.694

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