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GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3?/EMT axis

期刊: NEOPLASMA, 2023; 70 (1)

GOLM1 (Golgi membrane protein 1), a key tumor progression-and metastasis-related marker, is highly expressed in a variety of epithelium-derived human ......

Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia

期刊: NEOPLASMA, 2023; 70 (2)

The 5-year overall survival rate of acute myeloid leukemia (AML) is less than 30%. Improving clinical outcomes is still a clinical challenge for AML t......

The inhibition of Aurora A kinase regulates phospholipid remodeling by upregulating LPCAT1 in glioblastoma

期刊: NEOPLASMA, 2023; 70 (2)

Metabolic reprogramming is a common feature of glioblastoma (GBM) progression and metastasis. Altered lipid metabolism is one of the most prominent me......

Tumor-targeted suicide gene-directed enzyme prodrug therapy mediated by extracellular vesicles

期刊: NEOPLASMA, 2023; 70 (3)

In this article, we describe the gene-directed enzyme prodrug therapy, also known as the Trojan Horse therapy mediated by exosomes - small extracellul......

Urinary shedding of common DNA viruses and their possible association with bladder cancer: a qPCR-based study

期刊: NEOPLASMA, 2023; 70 (2)

After a decade of human urinary microbiota research, little is known about the composition of the urinary virome and its association with health and d......

GPX3 is a key cholesterol-related gene associated with prognosis and tumorinfiltrating T cells in colorectal cancer

期刊: NEOPLASMA, 2023; 70 (5)

High cholesterol is an important factor inducing colorectal cancer (CRC). The study aims to determine the key genes and regulatory mechanism associate......

Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer

期刊: NEOPLASMA, 2023; 70 (5)

Radiotherapy and chemotherapy have improved the 5-year survival rate of nasopharyngeal carcinoma (NPC) patients, but the side effects generally lead t......

The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis

期刊: NEOPLASMA, 2023; 70 (4)

The purpose of this study was to assess the potential effects of Rhus coriaria L. (sumac) and of Cinnamomum zeylanicum L. bark on the selected serum c......

Sintilimab, bevacizumab biosimilar, and HAIC for unresectable hepatocellular carcinoma conversion therapy: a prospective, single-arm phase II trial

期刊: NEOPLASMA, 2023; 70 (6)

We assessed the efficacy and safety of sintilimab [an anti-programmed death (PD-1)] plus bevacizumab biosimilar (IBI305), and hepatic arterial infusio......

FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells

期刊: NEOPLASMA, 2023; 70 (6)

F-box and WD repeat domain containing 7 (FBXW7) is an aboriginal and high-frequency mutant gene associated with esophageal squamous cell carcinoma (ES......

Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis

期刊: NEOPLASMA, 2023; 70 (1)

Zerumbone had been verified as a potential anti-cancer agent. Our research aimed to investigate the effect of zerumbone combined with gefitinib in lun......

Novel model of triple-negative breast cancer produces viable circulating tumor cells and rapid lung metastasis for functional testing in vivo

期刊: NEOPLASMA, 2023; 70 (4)

Breast cancer metastases are the main reason for women ' s highest cancer mortality. Even though tumor cell dissemination via circulating tumor cells ......

NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway

期刊: NEOPLASMA, 2023; 70 (2)

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is highly expressed in a variety of malignant tumors and functions as an on......

Comprehensive analysis of the PTPN13 expression and its clinical implication in breast cancer

期刊: NEOPLASMA, 2023; 70 (2)

Protein tyrosine phosphatases non-receptor 13 (PTPN13) could be a potential biomarker in breast cancer (BRCA), but its genetic variation and biologica......

Hydrogel-based miR-192 delivery inhibits the development of hepatocellular carcinoma by suppressing the GSK3β/Wnt/β-catenin pathway

期刊: NEOPLASMA, 2023; 70 (4)

Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by high invasiveness, metastasis, and poor prognosis, which lacks effective tre......

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