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CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage

期刊: PHARMACOLOGICAL RESEARCH, 2023; 196 ()

Microglia are first responders to acute brain insults and initiate neuroinflammation to drive secondary tissue injury. Yet the key molecular switches ......

A systematic mapping review of the evolution of the rat Forced Swim Test: Protocols and outcome parameters

期刊: PHARMACOLOGICAL RESEARCH, 2023; 196 ()

As depression is projected to become the leading mental disease burden globally by 2030, understanding the underlying pathology, as well as screening ......

Super-enhancer-associated SNHG15 cooperating with FOSL1 contributes to bladder cancer progression through the WNT pathway

期刊: PHARMACOLOGICAL RESEARCH, 2023; 197 ()

Small nucleolar RNA host gene 15 (SNHG15) plays an oncogenic role in many cancers. However, the role of SNHG15 in bladder cancer (BLCA) remains unclea......

Effects of carrimycin on biomarkers of inflammation and immune function in tumor patients with sepsis: A multicenter double-blind randomized controlled trial

期刊: PHARMACOLOGICAL RESEARCH, 2023; 198 ()

Carrimycin is a potential immune-regulating agent for sepsis in patients with tumors. In this study, we inves-tigated its effects on inflammation and ......

Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis?

期刊: PHARMACOLOGICAL RESEARCH, 2023; 187 ()

Over the past few decades, the treatment of atherosclerotic cardiovascular disease has mainly been through an LDL lowering strategy and treatments tar......

Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain

期刊: PHARMACOLOGICAL RESEARCH, 2023; 187 ()

Neuropathic pain is a common health problem resulting in exacerbated response to noxious and non noxious stimuli, as well as impaired emotional and co......

Prognostic impacts of Lipoxin A4 in patients with acute myocardial infarction: A prospective cohort study

期刊: PHARMACOLOGICAL RESEARCH, 2023; 187 ()

Lipoxin A4 (LXA4) is one of the specialized pro-resolving lipid mediators proved to suppress the progression of atherosclerosis in vivo, but its clini......

Hydroxytyrosol decreases EDNRA expression through epigenetic modification in colorectal cancer cells

期刊: PHARMACOLOGICAL RESEARCH, 2023; 187 ()

The Mediterranean diet (MD) is one of the healthiest ones and is associated with a lower incidence of cardio-vascular and cerebrovascular diseases as ......

Large inherent variability in data derived from highly standardised cell culture experiments

期刊: PHARMACOLOGICAL RESEARCH, 2023; 188 ()

Cancer drug development is hindered by high clinical attrition rates, which are blamed on weak predictive power by preclinical models and limited repl......

Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?

期刊: PHARMACOLOGICAL RESEARCH, 2023; 191 ()

Oxidative stress (OS) is a chemical imbalance between an oxidant and an antioxidant, causing damage to redox signaling and control or causing molecula......

Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

期刊: PHARMACOLOGICAL RESEARCH, 2023; 193 ()

A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast ca......

MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis

期刊: PHARMACOLOGICAL RESEARCH, 2023; 194 ()

An emerging but less explored shared pathophysiology across microbiota-gut-brain axis disorders is aberrant miRNA expression, which may represent nove......

Dibenzocyclooctadiene lignans from the family Schisandraceae: A review of phytochemistry, structure-activity relationship, and hepatoprotective effects

期刊: PHARMACOLOGICAL RESEARCH, 2023; 195 ()

Liver injury is a common pathological process characterized by massive degeneration and abnormal death of liver cells. With increase in dead cells and......

Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond

期刊: PHARMACOLOGICAL RESEARCH, 2023; 197 ()

In the aftermath of tissue injury or infection, an efficient resolution mechanism is crucial to allow tissue healing and preserve appropriate organ fu......

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