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Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 577 ()

Liver cancer is one of the most common malignancies that is difficult to treat due to late diagnosis and chemo-resistance. In the present study, we de......

TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 577 ()

Gliomas are the major type of primary brain tumors. Accumulating research has demonstrated that tubulin is connected with the development and malignan......

LncRNA NONHSAT009968 inhibits the osteogenic differentiation of hBMMSCs in SA-induced inflammation via Wnt3a

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 577 ()

Osteomyelitis is one of the most challenging diseases in the field of orthopedics for its complex pathogenesis and unsatisfactory treatment. The mecha......

Protein-DNA complex structure modeling based on structural template

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 577 ()

DNA-binding is an important feature of proteins, and protein-DNA interaction involves in many life processes. Various computational methods have been ......

Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 568 ()

XIAP is multi-functional protein which regulates apoptosis acting as a direct caspase inhibitor. It is overexpressed in cancer cells, where it antagon......

The N-linked glycosylations of TIGIT Asn32 and Asn101 facilitate PVR/TIGIT interaction

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 562 ()

Although the PVR/TIGIT immune checkpoint axis has been suggested as a promising target for cancer immunotherapy and multiple TIGIT-targeting therapies......

Phenotype-based single cell sequencing identifies diverse genetic subclones in CD133 positive cancer stem cells

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 558 ()

Tumor heterogeneity is one of the ongoing huddles in the field of colon cancer therapy. It is evident that there are countless clones which exhibit di......

Differential mechanisms of synaptic plasticity for susceptibility and resilience to chronic social defeat stress in male mice

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 562 ()

Mood dysregulation refers to the inability of a person to control their negative emotions, and it is linked to various stressful experiences. Dysregul......

Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 561 ()

Doxorubicin (DOX) is a broad-spectrum antineoplastic drug; however, its serious cardiotoxic side effects in inflammatory responses limit its use in cl......

CBL-interacting protein kinase 31 regulates rice resistance to blast disease by modulating cellular potassium levels

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 563 ()

Rice blast disease caused by infection with Magnaporthe oryzae, a hemibiotrophic fungal pathogen, significantly reduces the yield production. However,......

Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 576 ()

Ras-related GTP binding (Rag) GTPases are required to activate mechanistic target of rapamycin complex 1 (mTORC1), which plays a central role in cell ......

Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 567 ()

Natural product-derived crude drugs are expected to yield an abundance of new drugs to treat infectious diseases. Hepatitis C virus (HCV) is an oncoge......

Structural study of the function of Candida Albicans Pif1

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 567 ()

Pif1 helicases, conserved in eukaryotes, are involved in maintaining genome stability in both the nucleus and mitochondria. Here, we report the crysta......

Histone and DNA binding ability studies of the NSD subfamily of PWWP domains

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 569 ()

The NSD proteins, namely NSD1, NSD2 and NSD3, are lysine methyltransferases, which catalyze mono and di-methylation of histone H3K36. They are multi-d......

Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to beta-catenin that requires AGR2 dimerization and adhesion domains

期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 573 ()

Anterior gradient 2 (AGR2) is often overexpressed in several types of cancer. AGR2 is cytoplasmic or secreted as an extracellular signal. Intracellula......

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