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Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2021; 49 (2)

Type 2 diabetes mellitus (T2DM) is one of the most common lifestyle-related diseases (metabolic disorders) due to hyperphagia and/or hypokinesia. Hype......

Novel insights into the pervasive role of RNA structure in post-transcriptional regulation of gene expression in plants

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2021; 49 (4)

RNA folding is an intrinsic property of RNA that serves a key role in every step of post-transcriptional regulation of gene expression, from RNA matur......

DNA methylation: from model plants to vegetable crops

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2021; 49 (3)

As a subgroup of horticultural crops, vegetable food is a kind of indispensable energy source for human beings, providing necessary nutritional compon......

Recent insight into the role of RING-finger E3 ligases in glioma

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2021; 49 (1)

The ubiquitin proteasome system(UPS) serves as the major posttranslational modification system for the maintenance of protein homeostasis. The ubiquit......

Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2021; 49 (1)

Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases associated with diverse cellular activities) family of protein......

The emerging roles of semaphorin4D/CD100 in immunological diseases

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (6)

In vertebrates, the semaphorin family of proteins is composed of 21 members that are divided into five subfamilies, i.e. classes 3 to 7. Semaphorins p......

Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (6)

The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 i......

The complexity of PRC2 catalysts CLF and SWN in plants

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (6)

Polycomb repressive complex 2 (PRC2) is an evolutionally conserved multisubunit complex essential for the development of eukaryotes. In Arabidopsis th......

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (6)

Next-generation sequencing (NGS) technologies - Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct ......

BMP9 is a potential therapeutic agent for use in oral and maxillofacial bone tissue engineering

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (3)

Oral and maxillofacial surgery is often challenging due to defective bone healing owing to the microbial environment of the oral cavity, the additiona......

Mammalian GPI-anchor modifications and the enzymes involved

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (3)

Glycosylphosphatidylinositol (GPI) is a glycolipid added to the C-terminus of a large variety of proteins in eukaryotes, thereby anchoring these prote......

Systems approach to rational combination therapy: PARP inhibitors

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (3)

Poly (ADP-ribose) polymerase inhibitors (PARPi) have demonstrated activity across a broad spectrum of molecular backgrounds and tumor types, with the ......

Decellularized bone extracellular matrix in skeletal tissue engineering

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (3)

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmac......

Genetically encoded selective cross-linkers and emerging applications

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (4)

There has been a large amount of interest in the development of genetically encoded cross-linkers that target functional groups naturally present in c......

Structure and function of Pygo in organ development dependent and independent Wnt signalling

期刊: BIOCHEMICAL SOCIETY TRANSACTIONS, 2020; 48 (4)

Pygo is a nuclear protein containing two conserved domains, NHD and PHD, which play important roles in embryonic development and carcinogenesis. Pygo ......

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