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MicroRNA-19b Downregulates NR3C1 and Enhances Oxaliplatin Chemoresistance in Colon Cancer via the PI3K/AKT/mTOR Pathway

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Background: Identifying the genes and signaling pathways related to chemoresistance might facilitate the development of novel therapeutic strategies f......

Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Lymphoid neoplasms encompass a heterogeneous group of malignancies with a predilection for immunocompromised individuals, and the disease burden of ly......

Primary Pleural Squamous Cell Carcinoma, Highly Positive PD-L1, Shows Marked Response to Camrelizumab: A Case Report

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Here, we reported the rare case of primary pleural squamous cell carcinoma (PPSCC) in a 71-year-old male patient. After chemo and targeted therapies, ......

Prognostic Nomogram for Patients With Pancreatic Ductal Adenocarcinoma of Pancreatic Head After Pancreaticoduodenectomy

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Background: The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) of pancreatic head remains poor, even after potentially curative R0......

High expression of cluster of differentiation 276 indicates poor prognosis in glioma

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Background: Glioma is the central nervous system tumor with the highest incidence rate and the molecular detection of gliomas has been the focus of re......

A novel germline BRCA1 mutation identified in a family with hereditary breast and ovarian cancer syndrome

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Pathogenic germline mutations occurring in the BRCA1 (MIM:113705) and BRCA2 (MIM: 600185), which always result in truncated protein or nonsense-mediat......

The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated great promise for treating cancers with homologous recombination (HR) defects, such a......

Machine Learning Can Predict Total Death After Radiofrequency Ablation in Liver Cancer Patients

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2021; 15 ()

OBJECTIVE: Over 1 million new cases of hepatocellular carcinoma (HCC) are diagnosed worldwide every year. Its prognosis remains poor. and the 5-year s......

Evolution of Lung Cancer in the Context of Immunotherapy

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2020; 14 ()

Immunotherapy, as a novel treatment, has brought new hope to many patients with cancer, including patients with lung cancer. However, the overall cure......

Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2020; 14 ()

PURPOSE: About one-third of nonsmall cell lung cancer (NSCLC) patients develop brain metastases (BM). However, there is an unmet need for early diagno......

Combining Genetic Mutation and Expression Profiles Identifies Novel Prognostic Biomarkers of Lung Adenocarcinoma

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2020; 14 ()

Motivation: Although several prognostic signatures for lung adenocarcinoma (LUAD) have been developed, they are mainly based on a single-omics data se......

A Diagnostic Nomogram of Pathologic Grade for Preoperative Risk Stratification in Upper Tract Urothelial Carcinoma

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2020; 14 ()

Background: To develop a novel nomogram to improve the preoperative diagnosis of pathological grade of upper tract urothelial carcinoma (UTUC). Method......

Local Therapy Combined With First-Line EGFR Tyrosine Kinase Inhibitor Achieves Favorable Survival in Patients With EGFR-Mutant Metastatic Non-Small Cell Lung Cancer

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2022; 16 ()

BACKGROUND: EGFR tyrosine kinase inhibitor (TKI) is recommended as the first-line therapy for patients with EGFR-mutant metastatic non-small cell lung......

Radiomics in Nasopharyngeal Carcinoma

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2022; 16 ()

Nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies, and the primary treatment methods are radiotherapy and chemothera......

Effect of Number of Retrieved Lymph Nodes on Prognosis in FIGO Stage IA1-IIA2 Cervical Cancer Patients Treated With Primary Radical Surgery

期刊: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2022; 16 ()

BACKGROUND: The influence of the number of removed lymph nodes (RLNs) on patients with early-stage cervical cancer (ESCC) is still questionable. The o......

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