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Tissue-specific engineering: 3D bioprinting in regenerative medicine

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 329 ()

Despite its complexity, the human body is composed of only four basic tissue types, namely epithelial, connective, muscular and nervous tissues. Notab......

Cocktail strategy for 'cold' tumors therapy via active recruitment of CD8+T cells and enhancing their function

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 334 ()

In immunotherapy, 'cold' tumors, with low T cells infiltration, hardly benefit from the treatment of immune checkpoint inhibitors (ICIs). To address t......

Metal-coordinated nanomedicine for combined tumor therapy by inducing paraptosis and apoptosis

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 336 ()

Apoptosis resistance of tumor cells often results in chemoresistance and treatment failure in clinic. In this work, a Cu2+-coordinated morusin/doxorub......

GANDA: A deep generative adversarial network conditionally generates intratumoral nanoparticles distribution pixels-to-pixels

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 336 ()

Intratumoral nanoparticles (NPs) distribution is critical for the success of nanomedicine in imaging and treatment, but computational models to descri......

Microfluidic fabrication of inhalable large porous microspheres loaded with H2S-releasing aspirin derivative for pulmonary arterial hypertension therapy

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 329 ()

Hydrogen sulfide (H2S) has recently emerged as a novel gaseous mediator with protective actions in the treatment of pulmonary arterial hypertension (P......

Serum protein-based nanoparticles for cancer diagnosis and treatment

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 329 ()

Serum protein as naturally essential biomacromolecules has recently emerged as a versatile carrier for diagnostic and therapeutic drug delivery for ca......

Advances in receptor modulation strategies for flexible, efficient, and enhanced antitumor efficacy

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 333 ()

Tumor-sensitivity, effective transport, and precise delivery to tumor cells of nano drug delivery systems (NDDs) have been great challenges to cancer ......

Improving anti-PD-L1 therapy in triple negative breast cancer by polymer-enhanced immunogenic cell death and CXCR4 blockade

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 334 ()

Triple negative breast cancer (TNBC) with highly metastatic features generally does not respond to anti-programmed cell death 1 ligand 1 (PD-L1) thera......

Magnetic nanoparticles for cancer theranostics: Advances and prospects

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 335 ()

Cancer is one of the leading causes of mortality worldwide. Nanoparticles have been broadly studied and emerged as a novel approach in diagnosis and t......

Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 329 ()

Intracellular methicillin-resistant Staphylococcus aureus (MRSA) is extremely difficult to remove by common antibiotics, leading to infection recurren......

Controlled drug delivery systems in eradicating bacterial biofilm-associated infections

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 329 ()

Drug delivery systems (DDS) have extensively progressed over the past decades for eradicating the bacteria embedded in biofilms while minimizing the s......

HCPT-peptide prodrug with tumor microenvironment -responsive morphology transformable characteristic for boosted bladder tumor chemotherapy

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 330 ()

As a common method for postoperative adjuvant treatments of bladder tumor, chemotherapy encounters low tumor targeting, short tumor retention time and......

Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 333 ()

An appropriate delivery system can improve the immune effects of antigens against various infections or tumors. Antigen-presenting cells (APCs) are sp......

Targeting therapy for prostate cancer by pharmaceutical and clinical pharmaceutical strategies

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 333 ()

For the past few years, nanotechnology has provided a lot of new treatment opportunities for prostate cancer patients, and brilliant achievements have......

Eradication of large established tumors by drug-loaded bacterial particles via a neutrophil-mediated mechanism

期刊: JOURNAL OF CONTROLLED RELEASE, 2021; 334 ()

The treatment of large established tumors remains a significant challenge and is generally hampered by poor drug penetration and intrinsic drug resist......

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