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The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated alpha-MSH in keratinocytes via Nrf2-mediated antioxidant pathways

期刊: REDOX BIOLOGY, 2021; 44 ()

Pterostilbene (Pt) is a natural polyphenol found in blueberries and several grape varieties. Pt's pharmacological importance was well documented. Neve......

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

期刊: REDOX BIOLOGY, 2021; 38 ()

Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a fermptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX......

bFGF alleviates diabetes-associated endothelial impairment by downregulating inflammation via S-nitrosylation pathway

期刊: REDOX BIOLOGY, 2021; 41 ()

Protein S-nitrosylation is a reversible protein modification implicated in both physiological and pathophysiological regulation of protein function. H......

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

期刊: REDOX BIOLOGY, 2021; 45 ()

Ferroptosis is primarily triggered by a failure of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) reductive system and associated overwhelming ......

Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney

期刊: REDOX BIOLOGY, 2021; 39 ()

Background: Renal ischemia-reperfusion (IR) injury is a common cause of acute kidney injury (AKI), which is associated with oxidative stress and reduc......

Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury

期刊: REDOX BIOLOGY, 2021; 38 ()

Oxidative stress is considered one of the early underlying contributors of acute lung injury (ALI) and ventilator-induced lung injury (VILI). DJ-1, al......

Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species

期刊: REDOX BIOLOGY, 2021; 39 ()

Reactive oxygen species (ROS) contribute to cellular redox environment and serve as signaling molecules. Excessive ROS can lead to oxidative stress th......

The tryptic peptides of hemoglobin for diagnosis of type 2 diabetes mellitus using label-free and standard-free LC-ESI-DMRM

期刊: REDOX BIOLOGY, 2021; 43 ()

N-1-(deoxyfructosyl) valine of beta-hemoglobin, commonly referred to as HbA1c, is the "gold standard" for clinical detection of diabetes. Instead of q......

p38 alpha in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1

期刊: REDOX BIOLOGY, 2021; 38 ()

Background: Macrophages regulate the inflammatory response and affect re-endothelialization. Inflammation and macrophages play important roles in prom......

Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy

期刊: REDOX BIOLOGY, 2021; 38 ()

Chronic alcoholism disrupts mitochondrial function and often results in alcoholic cardiomyopathy (ACM). Fas-activated serine/threonine kinase (FASTK) ......

ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance

期刊: REDOX BIOLOGY, 2021; 43 ()

Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for many chemotherapeutics, while resettled redox homeostasis i......

Endothelial specific deletion of HMGB1 increases blood pressure and retards ischemia recovery through eNOS and ROS pathway in mice*

期刊: REDOX BIOLOGY, 2021; 41 ()

Recent studies demonstrated HMGB1, an extracellular inflammation molecule, played an important role on endothelial cells. This study aimed to define t......

Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: Implications in Parkinson?s disease

期刊: REDOX BIOLOGY, 2021; 41 ()

Emerging evidence indicates that unexpected lipid droplet (LD) deposition and peroxidation can accelerate organelle stress and plays a crucial role in......

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

期刊: REDOX BIOLOGY, 2021; 44 ()

Activated microglia are an important type of innate immune cell in the brain, and they secrete inflammatory cytokines into the extracellular milieu, e......

Nanomedicine promotes ferroptosis to inhibit tumour proliferation in vivo

期刊: REDOX BIOLOGY, 2021; 42 ()

miR-101?3p may play a therapeutic role in various tumours. However, its anti-tumour mechanism remains unclear, and a definitive strategy to treat tumo......

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