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Dark DNA and stress (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (1)

Over the past few decades, research at the molecular level has focused on the part of the genome that does not encode protein sequences. Since the dis......

Overexpression of salusin-a upregulates AdipoR2 and activates the PPARa/ApoA5/SREBP-1c pathway to inhibit lipid synthesis in HepG2 cells

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (5)

Salusin-a and adiponectin, are vasoactive peptides with numerous similar biological effects related to lipid metabolism. Adiponectin has been shown to......

Pro-differentiating compounds for human intervertebral disc cells are present in Violina pumpkin leaf extracts

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (5)

Intervertebral disc (IVD) degeneration (IDD) is closely associated with inflammation, oxidative stress and loss of the discogenic phenotype, which cur......

Involvement of the JNK/HO-1/FTH1 signaling pathway in nanoplastic-induced inflammation and ferroptosis of BV2 microglia cells

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (1)

Nanoplastics (NPs) are a newly discovered type of environmental pollutant. The potential for neurotoxicity caused by NPs and their mechanisms are uncl......

Adropin attenuates pancreatitis-associated lung injury through PPAR? phosphorylation-related macrophage polarization

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (4)

Acute pancreatitis (AP)-associated lung injury (ALI) is a critical complication of AP. Adropin is a regulatory protein of immune metabolism. The prese......

Upregulation of MTHFD2 is associated with PD-L1 activation in bladder cancer via the PI3K/AKT pathway

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (2)

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been implicated in the etiology of various human malignant tumors; however, its exact role in b......

Role of gut microbiota in the modulation of the health effects of advanced glycation end-products (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (5)

The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) a......

Paeonia lactiflora root decreases lipid accumulation through the induction of lipolysis and thermogenesis via AMPK activation in 3T3-L1 cells

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (2)

Obesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, ......

METTL14-mediated RNA methylation in digestive system tumors

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (3)

N6-methyladenosine (m6A) RNA methylation is one of the most common post-transcriptional modification mechanism in eukaryotes. m6A is involved in almos......

Association of endometriosis with cardiovascular disease: Genetic aspects (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (3)

Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that affect the heart or blood vessels, including sequelae that ari......

13-cis-retinoic acid inhibits the self-renewal, migration, invasion and adhesion of cholangiocarcinoma cells

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (3)

13-cis-retinoic acid (13CRA), a Food and Drug Administration-approved drug for severe acne, is currently being investigated for its potential use in s......

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 51 (6)

Ferroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive produ......

Epstein-Barr virus as a promoter of tumorigenesis in the tumor microenvironment of breast cancer (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (2)

Epstein-Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC). EBV-associated oncogenesis requires the acti......

Bone marrow mesenchymal stem cell-derived exosomes: A novel therapeutic agent for tendon-bone healing (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023; 52 (6)

In sports medicine, injuries related to the insertion of tendons into bones, including rotator cuff injuries, anterior cruciate ligament injuries and ......

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