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Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes

期刊: CIRCULATION RESEARCH, 2022; 131 (5)

Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was ......

JIF:7.711

MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1

期刊: CIRCULATION RESEARCH, 2022; 130 (11)

Background: Mechanical forces play crucial roles in neointimal hyperplasia after vein grafting; yet, our understanding of their influences on vascular......

JIF:7.711

Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

期刊: CIRCULATION RESEARCH, 2022; 130 (7)

Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation and migration and impaired angiog......

JIF:7.711

Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS

期刊: CIRCULATION RESEARCH, 2022; 130 (9)

BACKGROUND: Cerebral small vessel injury, including loss of endothelial tight junctions, endothelial dysfunction, and blood-brain barrier breakdown, i......

JIF:7.711

Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart

期刊: CIRCULATION RESEARCH, 2022; 130 (11)

Background: Macrophages play an important role in cardiac repair after myocardial infarction (MI). In addition to the resident macrophages and blood-d......

JIF:7.711

Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification

期刊: CIRCULATION RESEARCH, 2022; 131 (12)

Background:Vascular calcification is closely related to the all-cause mortality of cardiovascular events. Basement membrane protein nidogen-2 is a key......

JIF:7.711

Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis

期刊: CIRCULATION RESEARCH, 2022; 131 (9)

Background: Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide......

JIF:7.711

Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS

期刊: CIRCULATION RESEARCH, 2022; 131 (2)

Background: The ADRB3 (beta 3-adrenergic receptors), which is predominantly expressed in brown adipose tissue (BAT), can activate BAT and improve meta......

JIF:7.711

Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts

期刊: CIRCULATION RESEARCH, 2022; 131 (6)

Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and plac......

JIF:7.711

Unspliced XBP1 Counteracts beta-Catenin to Inhibit Vascular Calcification

期刊: CIRCULATION RESEARCH, 2022; 130 (2)

Background: Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity and mor......

JIF:7.711

The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy

期刊: CIRCULATION RESEARCH, 2022; 130 (10)

Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure with highly complicated pathogeneses. The E3 ligase TRIM16 ......

JIF:7.711

Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates

期刊: CIRCULATION RESEARCH, 2022; 130 (3)

Background: Unraveling how new coronary arteries develop may provide critical information for establishing novel therapeutic approaches to treating is......

JIF:7.711

Therapeutic and Prognostic Significance of Arachidonic Acid in Heart Failure

期刊: CIRCULATION RESEARCH, 2022; 130 (7)

BACKGROUND: Accurate prediction of death is an unmet need in patients with acute decompensated heart failure (HF). Arachidonic acid (AA) metabolites p......

JIF:7.711

MST1 Suppresses Disturbed Flow Induced Atherosclerosis

期刊: CIRCULATION RESEARCH, 2022; 131 (9)

Background: Atherosclerosis occurs mainly at arterial branching points exposed to disturbed blood flow. How MST1 (mammalian sterile 20-like kinase 1),......

JIF:7.711

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