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Associations of Alcohol Consumption with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Pathology in Cognitively Intact Older Adults: The CABLE Study

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 82 (3)

Background: The relationship between alcohol consumption and Alzheimer's disease (AD) pathology is unclear. Amyloid-beta (A beta) and tau biomarkers i......

Olfactory Dysfunction Is Already Present with Subjective Cognitive Decline and Deepens with Disease Severity in the Alzheimer's Disease Spectrum

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 79 (2)

Background: Odor identification dysfunction occurs early in Alzheimer's disease (AD) and is considered a preclinical symptom along with subjective cog......

Associations of Dietary Pattern and Sleep Duration with Cognitive Decline in Community-Dwelling Older Adults: A Seven-Year Follow-Up Cohort Study

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 82 (4)

Background: A few studies have linked dietary patterns and sleep to cognitive decline. Objective: To examine the independent and joint associations of......

Dynamic Change of Intracellular Metabolism of Microglia Evaluated by Transcriptomics in an Alzheimer's Mouse Model

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 81 (2)

Background: Microglia play diverse roles in Alzheimer's disease (AD). Intracellular metabolism has been indicated an important factor in modulating th......

Left Ventricular Ejection Fraction and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Pathology in Cognitively Normal Older Adults: The CABLE Study

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 81 (2)

Background: Heart failure has been considered as a potential modifiable risk factor for cognitive impairment and dementia. Left ventricular ejection f......

Insomnia Moderates the Relationship Between Amyloid-beta and Cognitive Decline in Late-Life Adults without Dementia

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 81 (4)

Background: It is suggested that not all individuals with elevated A beta will develop dementia or cognitive impairment. Environment or lifestyle migh......

Synergistic Effects of APOE and CLU May Increase the Risk of Alzheimer's Disease: Acceleration of Atrophy in the Volumes and Shapes of the Hippocampus and Amygdala

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 80 (3)

Background: The volume loss of the hippocampus and amygdala in non-demented individuals has been reported to increase the risk of developing Alzheimer......

Identification of Blood-Based Glycolysis Gene Associated with Alzheimer's Disease by Integrated Bioinformatics Analysis

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 83 (1)

Background: Alzheimer's disease (AD) is one of many common neurodegenerative diseases without ideal treatment, but early detection and intervention ca......

Deletion of Dcf1 Reduces Amyloid-beta Aggregation and Mitigates Memory Deficits

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 81 (3)

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease. One of the pathologies of AD is the accumulation of amyloid-beta (A b......

Altered Neuroanatomical Asymmetries of Subcortical Structures in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 79 (3)

Background: Individuals with subjective cognitive decline (SCD), defined by self-reported memory complaints but normal performance in objective neurop......

Core-Centered Connection Abnormalities Associated with Pathological Features Mediate the Progress of Cognitive Impairments in Alzheimer's Disease Spectrum Patients

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 82 (4)

Background: Abnormal default mode network (DMN) was associated with the progress of Alzheimer's disease (AD). Rather than treat the DMN as a unitary n......

Correlation Between Brain F-18-AV45 and F- 18-FDG PET Distribution Characteristics and Cognitive Function in Patients with Mild and Moderate Alzheimer's Disease

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 79 (3)

Background: Florbetapir (AV45) and fluorodeoxyglucose (FDG) PET imaging are valuable techniques to detect the amyloid-beta (A beta) load and brain glu......

Impaired Memory Awareness and Loss Integration in Self-Referential Network Across the Progression of Alzheimer's Disease Spectrum

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 83 (1)

Background: Anosognosia, or unawareness of memory deficits, is a common manifestation of Alzheimer's disease (AD), but greatly variable in subjective ......

Inhibition of miR-96-5p May Reduce A beta(42)/A beta(40) Ratio via Regulating ATP-binding cassette transporter A1

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 83 (1)

Background: Imbalance between amyloid-beta (A beta) production and clearance results in A beta accumulation. Regulating A beta levels is still a hot p......

Atrophic Pattern of Hippocampal Subfields in Post-Stroke Demented Patient

期刊: JOURNAL OF ALZHEIMERS DISEASE, 2021; 80 (3)

Background: Previous studies have demonstrated that hippocampal atrophy is a hallmark of dementia and can be used to predict the outcome of post-strok......

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