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Shigella escapes lysosomal degradation through inactivation of Rab31 by IpaH4.5

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (7)

Introduction. Shigella flexneri is an intracellular bacterial pathogen that utilizes a type III secretion apparatus to inject effector proteins into h......

Difference in drug susceptibility distribution and clinical characteristics between Mycobacterium avium and Mycobacterium intracellulare lung diseases in Shanghai, China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (5)

Introduction. Mycobacterium avium complex (MAC) has been reported as the most common aetiology of lung disease involving nontuberculous mycobacteria. ......

Emergence of carbapenem- resistant Klebsiella pneumoniae harbouring blaOXA-48-like genes in China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Klebsiella pneumoniae strains carrying OXA-48- like carbapenemases are increasingly prevalent across the globe. There is thus an urgent need to better......

Rifampin-resistance-associated mutations in the rifampin-resistance-determining region of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, PR China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Introduction. Resistance to rifampin (RIF) in Mycobacterium tuberculosis infection is associated with mutations in the rpoB gene coding for the fl-sub......

Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (7)

Introduction. Coronavirus disease 2019 (COVID-19) is a highly contagious disease and ravages the world. Hypothesis/Gap Statement. We proposed that R. ......

Molecular characterization of carbapenem-resistant Enterobacteriaceae and emergence of tigecycline non-susceptible strains in the Henan province in China: a multicentrer study

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Introduction. Carbapenem-resistant Enterobacteriaceae (CRE) have been responsible for nosocomial outbreaks worldwide and have become endemic in severa......

Characterization of a carbapenem- resistant Citrobacter amalonaticus coharbouring bla(IMP-4) and qnrs1 genes

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (6)

Introduction. Members of the genus Citrobacter are facultative anaerobic Gram-negative bacilli belonging to the Enterobacterales [Janda J Clin Microbi......

Phenotypic and genetic characteristics of Streptococcus mutans isolates from site-specific dental plaque in China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Introduction. Streptococcus mutans is an important cariogenic microbe. Hypothesis/Gap Statement. The potential characteristics of S. mutans isolates f......

Serum biomarkers to differentiate Gram-negative, Gram-positive and fungal infection in febrile patients

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (7)

Introduction. Contamination of specimens and overuse of broad spectrum antibiotics contribute to false positives and false negatives, respectively. Th......

Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Aim. This study aimed to investigate if the S. sonnei rough strain, by losing the virulence plasmid, interacted with APCs that express C- type lectins......

Fidaxomicin has high in vitro activity against Mycobacterium tuberculosis

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Tuberculosis (TB) is the leading cause of death from a single infectious agent, with an estimated 1.4 million deaths and 10.0 million new active TB pa......

Co-infections of two carbapenemase-producing Enterobacter hormaechei clinical strains isolated from the same diabetes individual in China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Introduction. Since mcr-1 was first reported in China, there have been ten variants of MCR appearing nationwide so far. Multidrug-resistant Enterobact......

Microbiological pattern of prosthetic hip and knee infections: a high-volume, single-centre experience in China

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

Introduction. Prosthetic joint infection (PJI) is a serious complication after arthroplasty, which results in high morbidity, prolonged treatment and ......

Profile of specific antibodies to the SARS- CoV-2

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (3)

In this work, we studied the profile of IgM and IgG antibody responses to SARS- CoV-2 in 32 patients with COVID-19 from day 1 to day 24. IgM remained ......

The clinical significance of simultaneous detection of pathogens from bronchoalveolar lavage fluid and blood samples by metagenomic next-generation sequencing in patients with severe pneumonia

期刊: JOURNAL OF MEDICAL MICROBIOLOGY, 2021; 70 (1)

Introduction. Bloodstream infection is a common complication in patients with severe pneumonia and is regarded as an independent risk factor for predi......

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