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Glycyl Radical Enzymes and Sulfonate Metabolism in the Microbiome

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021, 2021; 90 ()

Sulfonates include diverse natural products and anthropogenic chemicals and are widespread in the environment. Many bacteria can degrade sulfonates an......

A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021, 2021; 90 ()

Microbial natural products have provided an important source of therapeutic leads and motivated research and innovation in diverse scientific discipli......

How Is Precursor Messenger RNA Spliced by the Spliceosome?

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89, 2020; 89 ()

Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is mediated by the spliceosome. Together with biochemical and gen......

Small-Molecule-Based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88, 2019; 88 ()

Reactive oxygen species (ROS) encompass a collection of intricately linked chemical entities characterized by individually distinct physicochemical pr......

JIF:26.92

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87, 2018; 87 ()

Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors h......

JIF:26.92

Metalloproteomics for Biomedical Research: Methodology and Applications

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, 2022; 91 ()

Metals are essential components in life processes and participate in many important biological processes. Dysregulation of metal homeostasis is correl......

JIF:22.586

The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function

期刊: ANNUAL REVIEW OF BIOCHEMISTRY, 2022; 91 ()

The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in increasingly disruptive impacts, and it has become the most devast......

JIF:22.586

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