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Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 232 ()

Previous steroid hormone studies concerning pregnancy and newborns have mainly focused on glucocorticoids; wider steroid profiles have been less commo......

Identification and in vivo detection of side-chain hydroxylated metabolites of 413-hydroxycholesterol

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 234 ()

Oxysterols are oxidized derivatives of cholesterol that are formed by enzymatic processes or through the action of reactive oxygen species. Several of......

Cytotoxic effect of 13α-estrane derivatives on breast, endometrial and ovarian cancer cell lines

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 232 ()

Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occ......

YK11 induces oxidative stress and mitochondrial dysfunction in hippocampus: The interplay between a selective androgen receptor modulator (SARM) and exercise

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 233 ()

Our study investigates potential neurochemical effects of (17 & alpha;,20E)- 17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-2......

Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 225 ()

Various endocrinometabolic diseases, inclusively polycystic ovarian syndrome (PCOS) has been linked with increased risk of renal dysfunction with atte......

Metal-promoted synthesis of steroidal ethynyl selenides having anticancer activity

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 227 ()

In this study, we have described simple and efficient methodology for the metal-promoted (Cu2I2) preparation of steroidal ethynyl selenides. The compo......

Secosteroid-quinoline hybrids as new anticancer agents

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 228 ()

An elegant approach to unknown secosteroid-quinoline hybrids is disclosed. A series of 13,17-secoestra-1,3,5 (10)-trien-17-oic acid [N '-(iso)quinolyl......

Interactive metabolic signatures of testicular testosterone with bilateral adrenalectomy in mice

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 231 ()

The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes have reciprocal relationships with steroidogenesis regulation. ......

Progesterone receptor isoform ratios influence the transcriptional activity of progestins via the progesterone receptor

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 232 ()

Progestins (synthetic progestogens) are progesterone receptor (PR) ligands used globally by women in both hormonal contraception and menopausal hormon......

Small change-big consequence: The impact of C15-C16 double bond in a D-ring of estrone on estrogen receptor activity

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 233 ()

Estrogen receptor alpha (ER) is a key biomarker for breast cancer, and the presence or absence of ER in breast and other hormone-dependent cancers dec......

Functional analysis of vitamin D receptor (VDR) using adenovirus vector

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 230 ()

Recently, we generated type II rickets model rats, including Vdr(R270L), Vdr(H301Q), Vdr(R270L/H301Q), and Vdr-knockout (KO), by genome editing. All g......

The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 231 ()

The CYP124 and CYP142 families of bacterial cytochrome P450 monooxygenases (CYPs), catalyze the oxidation of methyl branched lipids, including cholest......

The 1,24,25(OH)3D3 metabolite in clinical and experimental CKD: Impact of calcitriol treatment

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 226 ()

Calcitriol, and other vitamin D receptor activators, remain a primary treatment for elevated parathyroid hormone levels in patients with end stage kid......

Serum and hair steroid profiles in patients with nonfunctioning pituitary adenoma undergoing surgery: A prospective observational study

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2023; 230 ()

Patients who undergo transsphenoidal surgery (TSS) experience perioperative hormonal changes, but there are few studies on the perioperative changes o......

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