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Assessing the clinical utility of genetic risk scores for targeted cancer screening

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these S......

beta-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

BackgroundLong-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-beta -glucan......

Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background Copy number variation (CNV) suggests genetic changes in malignant tumors. Abnormal expressions of long non-coding RNAs (lncRNAs) resulted f......

CHN1 promotes epithelial-mesenchymal transition via the Akt/GSK-3 beta/Snail pathway in cervical carcinoma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background: Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial-mesenchymal transitio......

Dissecting immune cell stat regulation network reveals biomarkers to predict ICB therapy responders in melanoma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the ......

Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

BackgroundPanic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cogn......

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here......

ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M......

Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, t......

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Background: The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and......

The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

IntroductionThe aim of the study was to systematically review relevant studies to evaluate the diagnostic value of urinary kidney injury molecule 1 (u......

The roles and mechanisms of hypoxia in liver fibrosis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2021; 19 (1)

Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or h......

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