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Novel single-domain antibodies against the EGFR domain III epitope exhibit the anti-tumor effect

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Monoclonal antibodies (mAbs) have been used for cancer therapy. They are large and have some disadvantages limiting their use. Smaller anti......

Development and validation of a robust immune-related prognostic signature in early-stage lung adenocarcinoma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundThe incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs fo......

Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundMolecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition ......

Gene correlation network analysis to identify regulatory factors in sepsis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background and objectives Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the diseas......

Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundAutoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and ......

Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundThe gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed betwe......

Association between telomere length in peripheral blood leukocytes and risk of ischemic stroke in a Han Chinese population: a linear and non-linear Mendelian randomization analysis

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic ......

Bioinformatic gene analysis for potential therapeutic targets of Huntington's disease in pre-symptomatic and symptomatic stage

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Huntington's disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Cert......

Connecting METTL3 and intratumoural CD33(+) MDSCs in predicting clinical outcome in cervical cancer

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundMethyltransferase-like 3 (METTL3) is a member of the m(6)A methyltransferase family and acts as an oncogene in cancers. Recent studies sugge......

LTBP1 plays a potential bridge between depressive disorder and glioblastoma

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological disorders......

Effect of early prophylactic low-dose recombinant human erythropoietin on retinopathy of prematurity in very preterm infants

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background: Very preterm infants are at risk of developing retinopathy of prematurity (ROP). Recombinant human erythropoietin (rhEPO) is routinely use......

Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic......

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Interleukin-6 (IL-6) was proposed to be associated with the severity of coronavirus disease 2019 (COVID-19). The present study aimed to exp......

Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hyperten......

Necessity for detection of SARS-CoV-2 RNA in multiple types of specimens for the discharge of the patients with COVID-19

期刊: JOURNAL OF TRANSLATIONAL MEDICINE, 2020; 18 (1)

Background The SARS-CoV-2 RNA was detected positive again after discharged from hospital in some COVID-19 patients, with or without clinical symptoms ......

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