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Long-term outcomes of the MICOF keratoprosthesis surgery

期刊: OCULAR SURFACE, 2021; 21 ()

Purpose: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat endstage corneal blindness. Design: Retrospec......

In-situ porcine corneal matrix hydrogel as ocular surface bandage

期刊: OCULAR SURFACE, 2021; 21 ()

Purpose: Bioactive substrates can be used therapeutically to enhance wound healing. Here, we evaluated the effect of an in-situ thermoresponsive hydro......

Clinical practice patterns in the management of dry eye disease: A TFOS international survey

期刊: OCULAR SURFACE, 2021; 21 ()

Purpose: To examine clinical management and prescribing patterns for dry eye disease (DED), in relation to severity and subtype, by eye care practitio......

Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease

期刊: OCULAR SURFACE, 2021; 20 ()

Purpose: To investigate the expression of pigment epithelium-derived factor (PEDF) in ocular surface in dry eye disease (DED) and its anti-inflammator......

Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea

期刊: OCULAR SURFACE, 2021; 20 ()

Purpose: This study aimed to uncover novel cell types in heterogenous basal limbus of human cornea for identifying LSC at single cell resolution. Meth......

Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture

期刊: OCULAR SURFACE, 2021; 21 ()

Purpose: To understand the relationship between ciliogenesis and autophagy in the corneal epithelium. Methods: siRNAs for EphA2 or PLD1 were used to i......

Developing evidence-based guidance for the treatment of dry eye disease with artificial tear supplements: A six-month multicentre, double-masked randomised controlled trial

期刊: OCULAR SURFACE, 2021; 20 ()

Purpose: To assess the six-month therapeutic profiles of lipid and non-lipid-based artificial tear supplements in managing dry eye disease (DED). Meth......

Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege

期刊: OCULAR SURFACE, 2021; 21 ()

Purpose: The corneal limbus maintains the homeostasis, immune and angiogenic privilege of cornea. This study aimed to depict the landscape of human li......

Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands

期刊: OCULAR SURFACE, 2021; 20 ()

Purpose: Jet lag causes a disruption in physiological rhythms in humans. This study aims to explore the extent to which jet lag affects the circadian ......

Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients

期刊: OCULAR SURFACE, 2021; 19 ()

Purpose: To investigate sex and age differences in symptoms and signs in a Norwegian clinic-based cohort of patients with dry eye disease (DED). Metho......

Organoids and organ chips in ophthalmology

期刊: OCULAR SURFACE, 2021; 19 ()

Recent advances have driven the development of stem cell-derived, self-organizing, three-dimensional miniature organs, termed organoids, which mimic d......

Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)

期刊: OCULAR SURFACE, 2020; 18 (2)

Purpose: To analyse the tear cytokine levels of patients diagnosed with ocular chronic graft-versus-host disease (GVHD)and examine the consistency of ......

High-fat diet induces dry eye-like ocular surface damages in murine

期刊: OCULAR SURFACE, 2020; 18 (2)

Purpose: A high-fat diet leads to dysfunction in multiple systems of the body. Herein we investigate the effects of a high-fat diet on the ocular surf......

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