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Upregulation of RIP3 promotes necroptosis via a ROS-dependent NF-kappa B pathway to induce chronic inflammation in HK-2 cells

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (5)

Tubular atrophy/interstitial fibrosis (TA/IF) is a major cause of late allograft loss, and inflammation within areas of TA/IF is associated with adver......

Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide-induced acute liver injury

期刊: MOLECULAR MEDICINE REPORTS, 2021; 23 (6)

Arsenic trioxide (ATO)-induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgI......

ROS-associated mechanism of different concentrations of pinacidil postconditioning in the rat cardiac Nrf2-ARE signaling pathway

期刊: MOLECULAR MEDICINE REPORTS, 2021; 23 (6)

Previous studies have confirmed that 50 mu mol/l pinacidil postconditioning (PPC) activates the nuclear factor-E2 related factor 2 (Nrf2)-antioxidant ......

CXCR3 alleviates renal ischemia-reperfusion injury via increase of Tregs

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (1)

Increasing evidence has demonstrated that regulatory T cells (Tregs) suppress innate immunity, as well as protect the kidneys from ischemia-reperfusio......

Selective inhibition of JNK mitochondrial location is protective against seawater inhalation-induced ALI/ARDS

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (1)

Localization of phosphorylated (p)-JNK to the mitochondria can lead to functional mitochondrial disorder, resulting in a decrease in energy supply and......

MicroRNA-142-3p suppresses cell proliferation, invasion and epithelial-to-mesenchymal transition via RAC1-ERK1/2 signaling in colorectal cancer

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (2)

Aberrant expression of microRNAs (miRNAs/miRs) is associated with the initiation and progression of colorectal cancer (CRC), but how they regulate col......

Blockage of Drp1 phosphorylation at Ser579 protects neurons against A beta(1-42)-induced degeneration

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (3)

Alzheimer's disease (AD), one of the most common types of chronic neurodegenerative diseases, is pathologically characterized by the formation of amyl......

Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (3)

Tight junctions (TJs) are an important component of cell connectivity; they maintain cell polarity, permeability and adhesion, and participate in the ......

Erastin-induced ferroptosis causes physiological and pathological changes in healthy tissues of mice

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (4)

Ferroptosis is a non-apoptotic form of cell death that relies on iron and lipid peroxidation, which is associated with multiple pathological processes......

Long non-coding RNA LINC00460 serves as a potential biomarker and oncogene via regulation of the miR-320b/PBX3 axis in acute myeloid leukemia

期刊: MOLECULAR MEDICINE REPORTS, 2021; 23 (6)

Long non-coding RNA 00460 (LINC00460) has been reported to be involved in the tumorigenesis of various cancer types. However, the function of LINC0046......

Hsa-circRNA-G004213 promotes cisplatin sensitivity by regulating miR-513b-5p/PRPF39 in liver cancer

期刊: MOLECULAR MEDICINE REPORTS, 2021; 23 (6)

In recent years, increasing evidence has confirmed that exosomal circular RNAs (circRNAs) serve a crucial role in the prognostic prediction and diagno......

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (3)

Papillary thyroid carcinoma is a common malignant tumor of the endocrine system. The specific role and molecular mechanism of potassium inwardly recti......

Long non-coding RNA HAND2-AS1/miR-106a/PTEN axis re-sensitizes cisplatin-resistant ovarian cells to cisplatin treatment

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (5)

Cisplatin (DDP) resistance in patients suffering from ovarian cancer is a considerable hurdle to successful treatment. The present study aimed to iden......

CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells

期刊: MOLECULAR MEDICINE REPORTS, 2021; 24 (1)

Cell division cycle-associated 2 (CDCA2) overexpression has been demonstrated to serve a significant role in tumorigenesis in certain types of cancer.......

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