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IL37 overexpression inhibits autophagy and apoptosis induced by hepatic ischemia reperfusion injury via modulating AMPK/mTOR/ULLK1 signalling pathways

期刊: LIFE SCIENCES, 2021; 276 ()

Aim: To investigate the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism. Methods: C57BL/6 mouse a......

Maresin 1 alleviates the inflammatory response, reduces oxidative stress and protects against cardiac injury in LPS-induced mice

期刊: LIFE SCIENCES, 2021; 277 ()

Background: Maresin 1 (MaR1) is a pro-resolving lipid mediator that has been reported to have strong regulatory effects on oxidative stress and inflam......

Adipocyte-secreted microvesicle-derived miR-148a regulates adipogenic and osteogenic differentiation by targeting Wnt5a/Ror2 pathway

期刊: LIFE SCIENCES, 2021; 278 ()

Aims: Adipocyte-secreted microvesicles (MVs)-derived microRNAs (miRNAs) are relevant to adipogenic and osteogenic differentiation of bone marrow mesen......

Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status

期刊: LIFE SCIENCES, 2021; 280 ()

Aims: Silent information regulator 1 (SIRT1) is a NAD+-dependent protein-modifying enzyme involved in regulating gene expression, DNA damage repair, c......

Resveratrol-mediated neurorestoration after cerebral ischemic injury-Sonic Hedgehog signaling pathway

期刊: LIFE SCIENCES, 2021; 280 ()

Aims: Resveratrol pretreatment can decrease ischemic cerebral injury and enhance proliferation of neural stem cells via mediation of Sonic Hedgehog si......

RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway

期刊: LIFE SCIENCES, 2021; 282 ()

R-spondins 2 (RSPO2) protein is a member of RSPO family which plays an essential role in stem cell survival, development and tumorigenicity. There has......

Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats

期刊: LIFE SCIENCES, 2021; 278 ()

Multidrug resistance gene (MDR1a) and P-glycoprotein (P-gp) play an important role in the development of ulcerative colitis (UC) and influence the the......

Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma

期刊: LIFE SCIENCES, 2021; 278 ()

Aims: The expression of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 were found to be downregulated in glioma by RNA sequencing; however, the......

Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis

期刊: LIFE SCIENCES, 2021; 278 ()

Objective: Pancreatic cancer (PC) cells-derived exosomes could mediate angiogenesis of human microvascular endothelial cells (HUVECs) in PC. Consideri......

Preclinical metabolic characterization of mefunidone, a novel anti-renal fibrosis drug

期刊: LIFE SCIENCES, 2021; 280 ()

Aims: The preclinical evaluation of innovative drugs plays an important role in the new drugs development. As a derivative of pirfenidone (PFD), mefun......

Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p

期刊: LIFE SCIENCES, 2021; 271 ()

Aims: Dysfunction of major cells constituting the aortic wall is the pathological basis for AD development. Determining whether non-coding RNAs can in......

The role of P2X7R in neuroinflammation and implications in Alzheimer's disease

期刊: LIFE SCIENCES, 2021; 271 ()

Alzheimer's disease (AD) is the most common cause of dementia and is set to rise in prevalence as the global trends in population aging. The extracell......

The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development

期刊: LIFE SCIENCES, 2021; 274 ()

Aims: Fibroblast growth factor 21 (FGF21) has been identified as the master hormonal regulator of energy balance, its elevation is observed in a serie......

Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway

期刊: LIFE SCIENCES, 2021; 275 ()

Aims: Defective tight junctions (TJs) can induce intestinal epithelial dysfunction, which participates in various diseases such as irritable bowel syn......

Role of microRNA-15a-5p/Sox9/NF-kappa B axis in inflammatory factors and apoptosis of murine nucleus pulposus cells in intervertebral disc degeneration

期刊: LIFE SCIENCES, 2021; 277 ()

Objective: MicroRNAs are well-established players in post-transcriptional gene modulation. We aim to explore the role of microRNA-15a-5p (miR-15a-5p)/......

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