期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (6)
Three highly pathogenic beta-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (6)
Cell-based, in vitro and in vivo assays reveal that Fanconi anemia factors function in a BRCA1-dependent BIR-like pathway to restart stalled replicati......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (7)
A series of high-resolution cryo-EM structures of substrate-engaged human p97 AAA ATPase reveal critical conformational changes of the intersubunit si......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (5)
Structural elucidation and functional analysis of the human GMPPA-GMPPB complex reveals how GMPPA acts as a 'sensor' of GDP-mannose to allosterically ......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, ; ()
Cryo-EM structures of the E. coli ABC transporter LolCDE in different functional states reveal mechanism of lipoprotein transport to the outer membran......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, ; ()
High-resolution cryo-EM structures of human RNA Pol III in both apo and elongating states provide insights into an autoinhibitory mechanism controllin......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (2)
RNA polymerase III (Pol III) synthesizes structured, essential small RNAs, such as transfer RNA, 5S ribosomal RNA and U6 small nuclear RNA. Pol III, t......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (1)
How can structural biology help us understand and combat SARS-CoV-2? Researchers in the field share their experiences and opinions and point to the ch......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (2)
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the formation of chromatin loops and topologically associating domain......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (2)
Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative stress when it was first linked to mutant superoxide dismuta......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (3)
Cryo-EM structures of the enzyme complexes catalyzing the rate-limiting step in sphingolipid synthesis reveal mechanisms of substrate recognition and ......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (3)
Human serine palmitoyltransferase (SPT) complex catalyzes the initial and rate-limiting step in the de novo biosynthesis of all sphingolipids. ORMDLs ......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (3)
The antiparasitic drug suramin directly inhibits SARS-CoV-2 RNA-dependent RNA polymerase by blocking binding of the RNA template-primer duplex and ent......
期刊： NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020; 27 (5)
Structural determination and analysis of the PHR domain of plant CRY proteins suggest that blue-light perception causes the CRY oligomerization requir......
