期刊: NATURE CELL BIOLOGY, 2022; 24 (3)
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PD......
期刊: NATURE CELL BIOLOGY, 2022; 24 (3)
As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the pro......
期刊: NATURE CELL BIOLOGY, 2022; 24 (4)
Autolysosomes contain components from autophagosomes and lysosomes. The contents inside the autolysosomal lumen are degraded during autophagy, while t......
期刊: NATURE CELL BIOLOGY, 2022; 24 (4)
d-2-Hydroxyglutarate (D-2HG) is an alpha-ketoglutarate-derived mitochondrial metabolite that causes d-2-hydroxyglutaric aciduria, a devastating develo......
期刊: NATURE CELL BIOLOGY, 2022; 24 (5)
Parental DNA methylation and histone modifications undergo distinct global reprogramming in mammalian pre-implantation embryos, but the landscape of e......
期刊: NATURE CELL BIOLOGY, 2022; 24 (6)
Various mechanisms contribute to membrane repair(1-3) but the machinery that mediates the repair of large wounds on the plasma membrane is less clear.......
期刊: NATURE CELL BIOLOGY, 2022; 24 (6)
In mammals, translational control plays critical roles during oocyte-to-embryo transition (OET) when transcription ceases. However, the underlying reg......
期刊: NATURE CELL BIOLOGY, 2022; 24 (11)
Transposon (de)repression and heterochromatin reorganization are dynamically regulated during cell fate determination and are hallmarks of cellular se......
期刊: NATURE CELL BIOLOGY, 2022; 24 (2)
Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemi......
期刊: NATURE CELL BIOLOGY, 2022; 24 (8)
Cellular senescence plays a causal role in ageing and, in mice, depletion of p16(INK4a)-expressing senescent cells delays ageing-associated disorders(......
期刊: NATURE CELL BIOLOGY, 2022; 24 (7)
Carbon dioxide not only plays a central role in the carbon cycle, but also acts as a crucial signal in living cells. Adaptation to changing CO2 concen......
期刊: NATURE CELL BIOLOGY, 2022; 24 (11)
Tumour cells exhibit greater metabolic plasticity than normal cells and possess selective advantages for survival and proliferation with unclearly def......
期刊: NATURE CELL BIOLOGY, 2022; 24 (5)
Zhang et al. report that a non-canonical cGAS-STING pathway activates PERK-eIF2 alpha to elaborate cap-dependent mRNA translation and contributes to s......
期刊: NATURE CELL BIOLOGY, 2022; 24 (4)
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall e......
期刊: NATURE CELL BIOLOGY, 2022; 24 (1)
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted ......