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Effects of gastroesophageal reflux disease treatment with proton pump inhibitors on the risk of acute exacerbation and pneumonia in patients with COPD

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

Background Gastroesophageal reflux disease (GERD) has been suggested as a risk factor for acute exacerbation of chronic obstructive pulmonary disease ......

Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundObesity has been identified as a risk factor for acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the underlying m......

Pseudomonas aeruginosa isolation is an important predictor for recurrent hemoptysis after bronchial artery embolization in patients with idiopathic bronchiectasis: a multicenter cohort study

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

Background Nearly half of bronchiectasis patients receiving bronchial artery embolization (BAE) still have recurrent hemoptysis, which may be life-thr......

Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

Background Hypoxia is associated with many respiratory diseases, partly due to the accumulation of edema fluid and mucus on the surface of alveolar ep......

Burden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundAsthma is a common disease in childhood and adolescence with lifelong consequences particularly among those at risk of severe disease, poor ......

Therapeutic properties of Helicobacter pylori-derived vacuolating cytotoxin A in an animal model of chronic allergic airway disease

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundIt has previously been shown that the Helicobacter pylori (H. pylori)-derived molecule vacuolating cytotoxin A (VacA) could be suitable for ......

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

Background Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the develop......

Protective effects of inhaled antioxidants against air pollution-induced pathological responses

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

As the public health burden of air pollution continues to increase, new strategies to mitigate harmful health effects are needed. Dietary antioxidants......

Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundDeep inspiration (DI) has been shown to induce bronchodilation and bronchoprotection in bronchochallenged healthy subjects, but not in asthm......

Do alternative tobacco products induce less adverse respiratory risk than cigarettes?

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

Rationale Due to the relatively short existence of alternative tobacco products, gaps exist in our current understanding of their long-term respirator......

Human airway tuft cells influence the mucociliary clearance through cholinergic signalling

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundAirway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies de......

COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundLung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID s......

Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundChronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease with high morbidity and mortality, especially in advance......

The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

BackgroundIdiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with limited treatment options. Interleukin-33 (IL-33) ......

Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease

期刊: RESPIRATORY RESEARCH, 2023; 24 (1)

The lungs, in addition to participating in gas exchange, represent the first line of defense against inhaled pathogens and respiratory toxicants. Cell......

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