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Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021; 22 (8)

Bacteriophage anti-CRISPR proteins evolved to counter CRISPR-Cas-mediated immunity in prokaryotes. Recent structural studies have provided novel insig......

Aldolase deployed for surveilling glucose

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (12)

Sheng-Cai Lin discusses discoveries implicating glycolytic enzyme, aldolase, in glucose sensing.

The ageing epigenome and its rejuvenation

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (3)

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several 'rejuvenating' ......

Mechanisms and regulation of cholesterol homeostasis

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (4)

Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease b......

The expanding regulatory mechanisms and cellular functions of circular RNAs

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (8)

Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in thei......

Guidelines and definitions for research on epithelial-mesenchymal transition

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (6)

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to......

CRISPR-Cas9 wins Nobel

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (12)

The discovery of the CRISPR-Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.

Voices of the new generation: science in a state of benign confusion

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (10)

Building a research group in China (when you have not mastered the language) means you face the same problems as elsewhere, with an extra bit of confu......

Applications of CRISPR-Cas in agriculture and plant biotechnology

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020; 21 (11)

The prokaryote-derived CRISPR-Cas genome editing technology has altered plant molecular biology beyond all expectations. Characterized by robustness a......

The role of 3D genome organization in development and cell differentiation

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2019; 20 (9)

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically packaged inside the nucleus. This complex genome organizat......

JIF:43.35

The future of CRISPR technologies in agriculture

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (5)

Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing ......

JIF:43.35

150 years of Darwin's theory of intercellular flow of hereditary information

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (12)

In 1868, Charles Darwin published his Pangenesis theory, which proposed a mechanism for the flow of hereditary information between cells and generatio......

JIF:43.35

Contextual determinants of TGF beta action in development, immunity and cancer

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (7)

Few cell signals match the impact of the transforming growth factor-beta (TGF beta) family in metazoan biology. TGF beta cytokines regulate cell fate ......

JIF:43.35

Dynamics and function of DNA methylation in plants

期刊: NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018; 19 (8)

DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylatio......

JIF:43.35

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