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Combinational therapeutic targeting of BRD4 and CDK7 synergistically induces anticancer effects in head and neck squamous cell carcinoma

期刊: CANCER LETTERS, 2020; 469 ()

The bromodomain and extra-terminal domain protein BRD4 has been recognized as a key oncogenic driver and a druggable target against cancer. However, t......

Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells

期刊: CANCER LETTERS, 2020; 469 ()

Emerging evidences show that dysregulation of circadian genes is closely associated with tumorigenesis. However, whether circadian genes regulate the ......

FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy

期刊: CANCER LETTERS, 2020; 469 ()

Docetaxel-mediated chemotherapy is the first line therapy for metastatic castration-resistant prostate cancer (CRPC) patients, but its therapeutic ben......

Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota

期刊: CANCER LETTERS, 2020; 469 ()

Gut microbiota dysbiosis is closely involved in intestinal carcinogenesis. A marked reduction in butyrate-producing bacteria has been observed in pati......

PAR2 deficiency enhances myeloid cell-mediated immunosuppression and promotes colitis-associated tumorigenesis

期刊: CANCER LETTERS, 2020; 469 ()

Protease-activated receptor 2 (PAR2) is a member of G-protein coupled receptors, which is widely expressed in intestinal epithelium and immune cells a......

LncRNA XLOC_006390 promotes pancreatic carcinogenesis and glutamate metabolism by stabilizing c-Myc

期刊: CANCER LETTERS, 2020; 469 ()

The role of lncRNAs in the regulation of glutamate metabolism and metabolic reprogramming of pancreatic cancer (PC) during nutrient deprivation is lar......

LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma

期刊: CANCER LETTERS, 2020; 469 ()

Metastasis is a core hallmark of cancer that leads to high mortality of cancer patients, especially in hepatocellular carcinoma (HCC). However, the un......

SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4

期刊: CANCER LETTERS, 2020; 469 ()

Metastasis is a major lethal cause of esophageal squamous cell carcinoma (ESCC) and confers a poor prognosis. Previous studies demonstrated that serpi......

TRAF7 enhances ubiquitin-degradation of KLF4 to promote hepatocellular carcinoma progression

期刊: CANCER LETTERS, 2020; 469 ()

The tumor necrosis factor receptor-associated factor 7 (TRAF7) is a component of the tumor necrosis factor alpha (TNF-alpha)/nuclear factor kappa B (N......

Irradiated lactic acid-stimulated tumour cells promote the antitumour immunity as a therapeutic vaccine

期刊: CANCER LETTERS, 2020; 469 ()

Low pH and lactate accumulation are characteristic features of the tumour microenvironment. With our study finding that high concentrations of lactic ......

Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer

期刊: CANCER LETTERS, 2020; 469 ()

Therapeutic biomacromolecules are confronted with in vivo challenges of low bio-stability and poor tumor tissue-penetration. Herein, we report for the......

Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma

期刊: CANCER LETTERS, 2020; 469 ()

Dysregulation of long noncoding RNA (lncRNA) H19 has been implicated in hepatocellular carcinoma (HCC), but the concrete regulatory mechanism is lack ......

SUMOylation homeostasis in tumorigenesis

期刊: CANCER LETTERS, 2020; 469 ()

Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in various biological processes, such as gene expression......

RACK1 promotes the invasive activities and lymph node metastasis of cervical cancer via galectin-1

期刊: CANCER LETTERS, 2020; 469 ()

Cervical cancer remains the first leading cause of cancer-related mortality among female reproductive system malignancies worldwide, and invasion and ......

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