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Inhibition of Histone Deacetylation by MS-275 Alleviates Colitis by Activating the Vitamin D Receptor

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (8)

Background: Ulcerative colitis [UC] is a common chronic inflammatory bowel disease without curative treatment. Methods: We conducted gene set enrichme......

Is Therapeutic Drug Monitoring for Anti-tumour Necrosis Factor Agents in Adults With Inflammatory Bowel Disease Ready for Standard of Care? A Systematic Review and Meta-analysis

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (8)

Introduction: Using therapeutic drug monitoring [TDM] in adult patients with inflammatory bowel disease [IBD] remains controversial. We conducted a sy......

Assessment of Endoscopic Healing by Using Advanced Technologies Reflects Histological Healing in Ulcerative Colitis

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (9)

Background: Several studies have reported that ulcerative colitis [UC] patients with endoscopic mucosal healing may still have histological inflammati......

Knowledge and Attitudes Towards Pregnancy in Females with Inflammatory Bowel Disease: An International, Multi-centre Study

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (9)

Background and Aims: Poor knowledge of inflammatory bowel disease [IBD] in pregnancy underlies unwarranted voluntary childlessness [VC], and risks poo......

COVID-19 Pandemic: Which IBD Patients Need to Be Scoped - Who Gets Scoped Now, Who Can Wait, and how to Resume to Normal

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 ()

Endoscopy is an essential component in the management of inflammatory bowel disease [IBD]. There is a risk of SARS-CoV-2 transmission during endoscopi......

Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (12)

Background: Macrophage-inducible C-type lectin [Mincle] signalling plays a proinflammatory role in different organs such as the brain and liver, but i......

Immunomodulatory Effect of Urine-derived Stem Cells on Inflammatory Bowel Diseases via Downregulating Th1/Th17 Immune Responses in a PGE(2)-dependent Manner

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (5)

Background and Aims: Despite the therapeutic promise of stem cell therapy in the treatment of inflammatory bowel diseases [IBD], most donor cell popul......

Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (5)

Background and Aims: Among the >240 genetic loci described to date which confer susceptibility to inflammatory bowel disease, a small subset have b......

Diagnosis and Outcome of Oesophageal Crohn's Disease

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (5)

Background and Aims: Crohn's disease [CD] can involve any part of the gastrointestinal tract. We aimed to characterize the clinical, endoscopic and hi......

Deletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (6)

Background and Aims: Interleukin 6 [IL-6] or its receptor is currently a candidate for targeted biological therapy of inflammatory bowel disease [IBD]......

Oral Targeted Delivery by Nanoparticles Enhances Efficacy of an Hsp90 Inhibitor by Reducing Systemic Exposure in Murine Models of Colitis and Colitis-Associated Cancer

期刊: JOURNAL OF CROHNS & COLITIS, 2020; 14 (1)

Background and Aims: Heat shock protein 90 [Hsp90]-targeted therapy has been proposed as a promising strategy for the treatment of ulcerative colitis ......

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