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Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (6)

Deep-learning models trained on retinal fundus images can be used to identify chronic kidney disease and type 2 diabetes and to predict the risk of th......

Advanced technologies for the preservation of mammalian biospecimens

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (8)

The three classical core technologies for the preservation of live mammalian biospecimens-slow freezing, vitrification and hypothermic storage-limit t......

Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (6)

An explainable deep-learning system prospectively predicts clinical scores for breast cancer risk from multimodal breast-ultrasound images as accurate......

A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (6)

An automated deep-learning pipeline for chest-X-ray-image standardization, lesion visualization and disease diagnosis can identify viral pneumonia cau......

Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (7)

Evaluating the biomechanics of soft tissues at depths well below their surface, and at high precision and in real time, would open up diagnostic oppor......

Erythrocyte-mediated systemic immunotherapy

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (5)

The restoration of a local chemokine gradient by nanoparticles non-covalently anchored on the surface of systemically administered red blood cells del......

Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (6)

The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the analysis of ctDNA biomarkers for the detection or monitoring of early-......

Prolonged activation of innate immune pathways by a polyvalent STING agonist

期刊: NATURE BIOMEDICAL ENGINEERING, ; ()

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that is a target of therapeutics for infectious diseases ......

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

期刊: NATURE BIOMEDICAL ENGINEERING, ; ()

Muscle loss and impairment resulting from traumatic injury can be alleviated by therapies using muscle stem cells. However, collecting sufficient numb......

Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres

期刊: NATURE BIOMEDICAL ENGINEERING, ; ()

During extracorporeal blood purification, anticoagulants are administered to prevent thrombogenesis. However, haemorrhagic complications owing to near......

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

期刊: NATURE BIOMEDICAL ENGINEERING, 2021; 5 (2)

Therapeutic genome editing requires effective and targeted delivery methods. The delivery of Cas9 mRNA using adeno-associated viruses has led to poten......

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (11)

The systemic biodistribution of endogenous extracellular vesicles is central to the maintenance of tissue homeostasis. Here, we show that angiogenesis......

A topical gel for extended ocular drug release

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (11)

The delivery of drugs to the eye can be prolonged via a gelling hypotonic solution that forms a clear thin layer on the eye's surface.

Adenine base editing in an adult mouse model of tyrosinaemia

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (1)

Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse mo......

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

期刊: NATURE BIOMEDICAL ENGINEERING, 2020; 4 (1)

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppresso......

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