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Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (5)

Aims The goal of our study was to investigate the heterogeneity of cardiac macrophages (CM phi s) in mice with transverse aortic constriction (TAC) vi......

JIF:5.353

MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (9)

Aims The heart undergoes pathological remodelling under increased stress and neuronal imbalance. MicroRNAs (miRNAs) are involved in post-transcription......

JIF:5.353

Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (7)

Aims The clinical use of antitumour agent doxorubicin (DOX) is hampered by its dose-dependent cardiotoxicity. Development of highly efficient and safe......

JIF:5.353

Trimethylamine N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (8)

Aims Recent studies have shown that the choline-derived metabolite trimethylamine N-oxide (TMAO) is a biomarker that promotes cardiovascular disease t......

JIF:5.353

The role of CD36 in cardiovascular disease

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (1)

CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely expressed in various organs. CD36 plays a crucial role in the upta......

JIF:5.353

Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (3)

Aims Ageing is the most significant contributor to the increasing prevalence of atrial fibrillation (AF). The gut microbiota dysbiosis is involved in ......

JIF:5.353

Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (9)

Aims Interleukin (IL)-5 mediates the development of eosinophils (EOS) that are essential for tissue post-injury repair. It remains unknown whether IL-......

JIF:5.353

Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (3)

Aims Congenital heart disease (CHD) frequently occurs in newborns due to abnormal formation of the heart or major blood vessels. Mutations in the GATA......

JIF:5.353

Updated perspectives on vascular cell specification and pluripotent stem cell-derived vascular organoids for studying vasculopathies

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (1)

Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect the haemostasis and physiological functions of all the v......

JIF:5.353

Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell-derived cardiomyocytes

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (12)

Aims Remdesivir is a prodrug of an adenosine triphosphate analogue and is currently the only drug formally approved for the treatment of hospitalized ......

JIF:5.353

Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (13)

Aims Abnormal intracellular calcium (Ca2+) handling contributes to the progressive nature of atrial fibrillation (AF), the most common sustained cardi......

JIF:5.353

Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (2)

Aims Fibroblast growth factor (FGF) 21, a key regulator of energy metabolism, is currently evaluated in humans for treatment of type 2 diabetes and no......

JIF:5.353

Association between BNT162b2 or CoronaVac COVID-19 vaccines and major adverse cardiovascular events among individuals with cardiovascular disease

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (10)

Aims Concern about the cardiovascular safety of coronavirus disease 2019 (COVID-19) vaccines among individuals with cardiovascular disease (CVD) may l......

JIF:5.353

Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (3)

Aims Macrophage-mediated inflammatory response represents a key pathophysiological process in a host of cardiovascular diseases including heart failur......

JIF:5.353

Anxa1 in smooth muscle cells protects against acute aortic dissection

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (6)

Aims Acute aortic dissection (AAD) is a life-threatening disease with high morbidity and mortality. Previous studies have showed that vascular smooth ......

JIF:5.353

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