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Matching-adjusted indirect comparison of asciminib versus other treatments in chronic-phase chronic myeloid leukemia after failure of two prior tyrosine kinase inhibitors

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (9)

PurposeThe current standard of care for chronic-phase chronic myeloid leukemia (CP-CML) is tyrosine kinase inhibitors (TKIs). Treatment recommendation......

Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (16)

PurposeResistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. H......

Anti-CD20-atezolizumab-polatuzumab vedotin in relapsed/refractory follicular and diffuse large B-cell lymphoma

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (2)

Purpose New therapies are needed for relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma. This phase 1b, open-label trial evaluated two anti-CD20-ba......

Effects of prior therapies on outcomes with trifluridine/tipiracil in patients with metastatic gastric/gastroesophageal junction cancer in a randomized phase III trial (TAGS)

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (11)

BackgroundIn the phase III TAGS trial, trifluridine/tipiracil showed survival benefit versus placebo in patients with metastatic gastric/gastroesophag......

Effects of immunosuppressive treatment on patient outcomes after immune checkpoint inhibitor-related gastrointestinal toxicity

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; ()

PurposeImmune checkpoint inhibitors (ICIs) are increasingly used in the treatment of certain cancers but cause immune-related adverse events (irAEs). ......

Diagnostic applications and therapeutic option of Cascade CRISPR/Cas in the modulation of miRNA in diverse cancers: promises and obstacles

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (12)

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas technology is a molecular tool specific to sequences for engineering genome......

Cancer detection in breast cells using a hybrid method based on deep complex neural network and data mining

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (14)

IntroductionDiagnosis of cancer in breast cells is an important and vital issue in the field of medicine. In this context, the use of advanced methods......

Comparison of PD-L1 expression and MMR status between primary and matched metastatic lesions in patients with cervical cancer

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (13)

PurposeProgrammed death-ligand 1 (PD-L1) and DNA mismatch repair (MMR) are considered predictive biomarkers for immunotherapy in cervical cancer. Howe......

Cell-free circulating RAS mutation concentrations significantly impact the survival of metastatic colorectal cancer patients

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (9)

PurposeRAS mutations are predictors of an adverse outcome in EGFR-targeted therapies and have been proposed as prognostic biomarkers of survival in me......

An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; ()

PurposePancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Endoplasmic reticulum stress (ERS) plays an essential role in PDAC......

Maternal and perinatal outcomes of pregnant patients with colorectal cancer: a population-based study

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (15)

PurposeThis study aimed to investigate the maternal and perinatal outcomes of pregnant patients with CRC using a large population-based database.Metho......

A novel antibody-TCR (AbTCR) T-cell therapy is safe and effective against CD19-positive relapsed/refractory B-cell lymphoma

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (7)

Purpose A barrier to widespread adoption of chimeric antigen receptor (CAR) T-cell therapy is toxicity. To address this, we recently developed a novel......

Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (19)

During eukaryotic gene expression, alternative splicing of messenger RNA precursors is critical in increasing protein diversity and regulatory complex......

hnRNP K induces HPV16 oncogene expression and promotes cervical cancerization

期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023; 149 (9)

PurposeThis study aims to explore the expression of hnRNP K in cervical carcinogenesis and to investigate the regulatory role of hnRNP K on HPV16 onco......

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