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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

期刊: ONCOGENE, 2023; 42 (12)

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains ......

BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms

期刊: ONCOGENE, 2023; 42 (8)

The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for......

Chemotherapy-induced tumor immunogenicity is mediated in part by megakaryocyte-erythroid progenitors

期刊: ONCOGENE, 2023; 42 (10)

Chemotherapy remains one of the main treatment modalities for cancer. While chemotherapy is mainly known for its ability to kill tumor cells directly,......

METTL3 stabilization by PIN1 promotes breast tumorigenesis via enhanced m6A-dependent translation

期刊: ONCOGENE, 2023; 42 (13)

Methyltransferase-like 3 (METTL3) is the catalytic subunit of the N-6-adenosine methyltransferase complex responsible for N-6-methyladenosine (m(6)A) ......

EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes

期刊: ONCOGENE, 2023; 42 (24)

Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in malignant gliomas. EZH2 and My......

A synergistic partnership between IL-33/ST2 and Wnt pathway through Bcl-xL drives gastric cancer stemness and metastasis

期刊: ONCOGENE, 2023; 42 (7)

ST2 functions as a receptor for the cytokine IL-33. It has been implicated in carcinogenesis. In this study, we sought to mechanistically determine ho......

TMIGD1: Emerging functions of a tumor supressor and adhesion receptor

期刊: ONCOGENE, 2023; 42 (22)

The development of multicellular organisms depends on cell adhesion molecules (CAMs) that connect cells to build tissues. The immunoglobulin superfami......

The strategy and clinical relevance of in vitro models of MAP resistance in osteosarcoma: a systematic review

期刊: ONCOGENE, 2023; 42 (4)

Over the last 40 years osteosarcoma (OS) survival has stagnated with patients commonly resistant to neoadjuvant MAP chemotherapy involving high dose m......

UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma

期刊: ONCOGENE, 2023; 42 (17)

Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within......

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

期刊: ONCOGENE, 2023; ()

Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable oc......

The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

期刊: ONCOGENE, 2023; 42 (11)

We have determined that expression of the pseudokinase NRBP1 positively associates with poor prognosis in triple negative breast cancer (TNBC) and is ......

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