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Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer's disease: a Mendelian randomization study

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Observational studies suggest that the use of antihypertensive medications (AHMs) is associated with a reduced risk of Alzheimer's disease ......

Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Neuronal hyperactivity related to beta-amyloid (A beta) is considered an early warning sign of Alzheimer disease (AD). Although increasing ......

Associations of healthy lifestyles with cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: the CABLE study

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Objective We aimed to investigate the associations between healthy lifestyles and Alzheimer's disease (AD) biomarkers in cerebrospinal fluid (CSF). Me......

Metformin attenuates plaque-associated tau pathology and reduces amyloid-beta burden in APP/PS1 mice

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-beta (A beta) plaques and neurofibrillary tangles (NFTs). The amylo......

Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Introduction Subjective cognitive decline (SCD) represents a cognitively normal state but at an increased risk for developing Alzheimer's disease (AD)......

Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer's disease by meta-analysis and adaptive boosting ensemble learning

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Blood circulating microRNAs that are specific for Alzheimer's disease (AD) can be identified from differentially expressed microRNAs (DEmiR......

Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background We aimed to investigate the tau biomarker discrepancies of Alzheimer's disease (AD) using plasma tau phosphorylated at threonine 181 (p-tau......

Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer's disease

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background: Accelerated long-term forgetting has been identified in preclinical Alzheimer's disease (AD) and is attributed to a selective impairment o......

Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of o......

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Plasma biomarkers showed a promising value in the disease diagnosis and management of Alzheimer's disease (AD). However, profiles of the bi......

Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and A beta clearance in APP/PS1 mice

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

BackgroundAlzheimer's disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Trichostatin A (T......

High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 x Tg) mouse model of Alzheimer's disease associated with chronic platelet activation

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background Epidemiological studies link vascular disease risk factors such as atherosclerosis, hypertension, and diabetes mellitus with Alzheimer's di......

Severe COVID-19 in Alzheimer's disease: APOE4's fault again?

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Challenges have been recognized in healthcare of patients with Alzheimer's disease (AD) in the COVID-19 pandemic, given a high infection and mortality......

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the "brain-gut" axis through multiple integrated omics

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

Background In recent years, excellent results have suggested an association between the "brain-gut" axis and Alzheimer's disease (AD) progression, yet......

Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects?

期刊: ALZHEIMERS RESEARCH & THERAPY, 2021; 13 (1)

BackgroundType 2 diabetes is a risk factor for Alzheimer's disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insuli......

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