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Predictive Models for HCC Prognosis, Recurrence Risk, and Immune Infiltration Based on Two Exosomal Genes: MYL6B and THOC2

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Introduction: Hepatocellular carcinoma (HCC) is a heterogeneous molecular disease with complex molecular pathogenesis that influences the efficacy of ......

Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Introduction: Quercetin was recently reported to help protect against osteoarthritis (OA) progression, but the molecular mechanism for that protective......

Expression Pattern and Clinical Value of Key m6A RNA Modification Regulators in Abdominal Aortic Aneurysm

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Background: Aberrant expression of N6-methyladenosine (m6A) RNA modification reg-ulators plays a critical role in a variety of human diseases. However......

Transcriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neatl in Experimental Ischemic Stroke

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Background: Ischemic stroke is one of the leading causes of mortality and disability worldwide. Following stroke, there is secondary neuroinflammation......

Role of Ferroptosis in Lung Diseases

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative str......

Helping Roles of Artificial Intelligence (AI) in the Screening and Evaluation of COVID-19 Based on the CT Images

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Objective: The aim of this study was to explore the role of the AI system which was designed and developed based on the characteristics of COVID-19 CT......

Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Aim: Sepsis, an acute, life-threatening dysregulated response to infection, affects practically all aspects of endothelial function. Tissue kallikrein......

An Indole-2-Carboxamide Derivative, LG4, Alleviates Diabetic Kidney Disease Through Inhibiting MAPK-Mediated Inflammatory Responses

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Aim: Elevated inflammatory signaling has been shown to play an important role in diabetic kidney disease (DKD). We previously developed a new anti-inf......

Prognostic and Predictive Value of Circulating Inflammation Signature in Non-Metastatic Nasopharyngeal Carcinoma: Potential Role for Individualized Induction Chemotherapy

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Purpose: We sought to assess the prognostic and predictive value of a circulating inflammation signature (CISIG) and develop CISIG-based tools for pre......

Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Background: Activation of vascular adventitial fibroblasts (VAFs) upon vascular injury contributes greatly to the medial vascular smooth muscle cells ......

Inflammasome as an Effective Platform for Fibrosis Therapy

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Fibrosis is the final stage of the development of chronic inflammation. It is characterized by excessive deposition of the extracellular matrix, leadi......

Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Purpose: Sjogren's syndrome (SS) is a systemic autoimmune disease mainly characterized by dysfunction of exocrine glands. Studies on diagnosis models ......

The lncRNA ANRIL Gene rs2151280 GG Genotype is Associated with Increased Susceptibility to Recurrent Miscarriage in a Southern Chinese Population

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Background: Genetic factors may play an important role in susceptibility to recurrent miscarriage. Some cardiovascular disease-related candidate genes......

Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Introduction: Ddb1-cullin4-associated-factor 1 (DCAF1) is known to regulate protein ubiquitination, while the roles of DCAF1 in osteomyelitis remain u......

The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

期刊: JOURNAL OF INFLAMMATION RESEARCH, 2021; 14 ()

Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-me......

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