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Sentinel node mapping for post-endoscopic resection gastric cancer: multicenter retrospective cohort study in Japan

期刊: GASTRIC CANCER, 2020; 23 (4)

Background Standard gastrectomy with systematic lymphadenectomy as an additional surgery after endoscopic resection (ER) causes a deterioration in lon......

Construction of(124)I-trastuzumab for noninvasive PET imaging of HER2 expression: from patient-derived xenograft models to gastric cancer patients

期刊: GASTRIC CANCER, 2020; 23 (4)

Purpose Here, we sought to develop a PET radioligand based on trastuzumab labeled with(124)I,I-124-trastuzumab, to evaluate its distribution, internal......

Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (6)

Background Fibroblast growth factor receptor 1 (FGFR1) is frequently dysregulated in various tumors. FGFR inhibitors have shown promising therapeutic ......

Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors

期刊: GASTRIC CANCER, 2020; 23 (5)

Background The majority of GISTs express mutationally activated KIT. Imatinib and sunitinib are approved KIT-inhibiting therapies. Their efficacy is u......

A deep learning method for delineating early gastric cancer resection margin under chromoendoscopy and white light endoscopy

期刊: GASTRIC CANCER, 2020; 23 (5)

Background Accurate delineation of cancer margins is critical for endoscopic curative resection. This study aimed to train and validate real-time full......

eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/beta-catenin in gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (3)

Background Epigenetic aberrations of tumor suppressor genes (TSGs), particularly DNA methylation, are frequently involved in the pathogenesis of gastr......

LBX2-AS1/miR-219a-2-3p/FUS/LBX2 positive feedback loop contributes to the proliferation of gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (3)

Background Long non-coding RNAs (lncRNAs) are increasingly investigated in numerous carcinomas containing gastric cancer (GC). The aim of our research......

Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (6)

Background Increasing evidence indicates that angiogenesis plays an important role in tumor progression. The function of cathepsin L (CTSL), an endoso......

Development and validation of a deep learning system for ascites cytopathology interpretation

期刊: GASTRIC CANCER, 2020; 23 (6)

Background Early diagnosis of Peritoneal metastasis (PM) is clinically significant regarding optimal treatment selection and avoidance of unnecessary ......

LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1

期刊: GASTRIC CANCER, 2020; 23 (6)

Background Emerging studies have shown that HOTAIR acts as an oncogene in gastric cancer (GC). However, its role in the extracellular matrix and in tu......

Laparoscopic total gastrectomy for upper-middle advanced gastric cancer: analysis based on lymph node noncompliance

期刊: GASTRIC CANCER, 2020; 23 (1)

Background Increasing number of clinical studies have shown that laparoscopic distal gastrectomy (LDG) with D2 lymph node (LN) dissection is an effect......

Survival after neoadjuvant approaches to gastroesophageal junction cancer

期刊: GASTRIC CANCER, 2020; 23 (1)

Background Gastroesophageal junction (GEJ) cancers can be treated with equipoise using neoadjuvant chemoradiation (NACRT) or chemotherapy alone (NAC),......

Convolutional neural network for the diagnosis of early gastric cancer based on magnifying narrow band imaging

期刊: GASTRIC CANCER, 2020; 23 (1)

Background Magnifying endoscopy with narrow band imaging (M-NBI) has been applied to examine early gastric cancer by observing microvascular architect......

Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors

期刊: GASTRIC CANCER, 2020; 23 (1)

Background Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has ......

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