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LncRNA AFAP1-AS1 modulates the sensitivity of paclitaxel-resistant prostate cancer cells to paclitaxel via miR-195-5p/FKBP1A axis

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (11)

LncRNA AFAP1-AS1 has been corroborated to function in diverse cancers. Our aim was to investigate the molecular mechanism of AFAP1-AS1 in PTX resistan......

Nivolumab induced hyperprogressive disease in advanced esophageal squamous cell carcinoma

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Immune checkpoint inhibitors have demonstrated promising efficacy and tolerable safety for advanced malignancies. However, a proportion of patients wh......

A novel prognostic biomarker for muscle invasive bladder urothelial carcinoma based on 11 DNA methylation signature

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Muscle-invasive bladder urothelial carcinoma (MIBC) is a highly invasive cancer, which leads to prevalent recurrence and poor prognosis. Exploring the......

Fruquintinib effectively controlled the advanced small bowel adenocarcinoma progressed after multiple lines of palliative treatment: a case report and literature review

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Small bowel cancer is a very rare disease. It can be treated by surgery at early stages; however, there is no standard therapeutic strategy establishe......

CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

A cornucopia of literatures has characterized the involvement of a host of functional molecules in liver cancer. Herein, according to online datasets,......

Primary squamous cell carcinoma of the breast: report of two cases with HER2 overexpression

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Objective To investigate the clinicopathologic features and immunophenotype of primary squamous cell carcinoma of the breast (PSCCB) with HER2 overexp......

The oncogenic role of SOX8 in endometrial carcinoma

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Endometrial carcinoma (EC) remains one of the most prevalent forms of cancer to impact the female reproductive system, yet the mechanisms governing it......

Obesity and metabolic syndrome related macrophage promotes PD-L1 expression in TNBC through IL6/JAK/STAT pathway and can be reversed by telmisartan

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Breast cancer is the most common malignant tumor in women. Its incidence is associated with obesity and metabolic syndrome (MetS), which are highly pr......

rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Bladder cancer is a common and widespread cancer of the human urinary system, and its incidence is increasing. Gene therapy is a promising treatment o......

miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (12)

Colon cancer is the third most common cancer worldwide. Many miRNAs have been reported to be involved in colon cancer progression. However, there are ......

LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (8)

Glioma is the most prevalent brain malignancy with high mortality. In recent decades, the regulatory role of long noncoding RNAs (lncRNAs) has been un......

Dysregulated circRNA_100876 contributes to proliferation and metastasis of colorectal cancer by targeting microRNA-516b (miR-516b)

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (8)

Colorectal cancer (CRC) is globally one of the most common malignant tumors. Increasing number of studies indicate that circular RNAs (circRNAs) play ......

Distinctive targetable genotypes of younger patients with lung adenocarcinoma: a cBioPortal for cancer genomics data base analysis

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (1)

There is still limited comprehensive genotyping data about young patients with lung adenocarcinoma. Herein, next generation sequencing (NGS) data of l......

Dexamethasone enhances the antitumor efficacy of Gemcitabine by glucocorticoid receptor signaling

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (4)

Gemcitabine (Gem) is currently used as the first-line therapy for liver and pancreatic cancer but has limited efficacy in most cases. Dexamethasone (D......

Associations between genetic polymorphisms in interleukin-10 and hematological oncology: evidence from a meta-analysis

期刊: CANCER BIOLOGY & THERAPY, 2020; 21 (4)

Background: Associations between polymorphisms in interleukin-10 (IL-10) and hematological oncology were already explored by many genetic association ......

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