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Reprogramming endothelial and vascular smooth muscle cells to prevent and treat hypertension

期刊: MEDICAL HYPOTHESES, 2023; 179 ()

The major pathophysiological characteristic of hypertension is the occurrence of small artery remodeling and endothelial dysfunction. There is also so......

The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention

期刊: MEDICAL HYPOTHESES, 2023; 181 ()

Immune cells such as Natural Killer (NK) cells play a central role in immunosurveillance, preserving the physiological integrity of tissues by fightin......

The prognostic value of androgen to PSA ratio in predictive modeling of prostate cancer

期刊: MEDICAL HYPOTHESES, 2023; 176 ()

Prostate specific antigen (PSA) is the ubiquitous biomarker used in mathematical and artificial intelligence models of prostate cancer. Yet, it is imp......

Early maladaptive schemas and depression: Epigenetics as a possible link

期刊: MEDICAL HYPOTHESES, 2023; 179 ()

Major depressive disorder (MDD) is a widespread mood disorder affecting millions of people. Because of heterogeneity and complexity of MDD, new hypoth......

Opioid ligands may act by blocking the muscarinic anti-inflammatory effect through allostericity in M1 receptors

期刊: MEDICAL HYPOTHESES, 2023; 180 ()

Muscarinic receptors are also involved in the cholinergic anti-inflammatory function through a central mechanism, as well as a peripheral one, which w......

Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation

期刊: MEDICAL HYPOTHESES, 2023; 181 ()

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause long-term neurological complications in adults. However, the mechanis......

The possible relation of ventilation ear tubes with nocturnal noise-induced discoordination of the stress response axis-Anatomical and physiological considerations

期刊: MEDICAL HYPOTHESES, 2023; 174 ()

Nocturnal noise above 30 dB Leq can impact the hypothalamus-pituitaryadrenal axis and discoordinate cortisol circadian rhythms, affecting, among other......

Law of precise matching and assembly chromosomes: A hypothesis for chromosome theory of inheritance and its implications in medical genetics

期刊: MEDICAL HYPOTHESES, 2023; 176 ()

It is well known that chromosome abnormalities are closely related to many diseases or disorders and devel-opmental abnormalities. However, our unders......

Microglia activation in paraventricular nucleus of hypothalamus: A self-help strategy for fetus born to preeclamptic mother

期刊: MEDICAL HYPOTHESES, 2023; 178 ()

Preeclampsia (PE) is a life-threatening pregnancy-specific disorder, characterized by new-onset hypertension after 20 weeks of gestation. It has been ......

Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis

期刊: MEDICAL HYPOTHESES, 2023; 174 ()

In inflammatory bowel disease (IBD), tissue damage and cell death occur, which are accompanied by the release of DNA into the extracellular space. Deo......

Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism

期刊: MEDICAL HYPOTHESES, 2023; 175 ()

Syringomyelia is characterized by the dilation of the central canal (CC) in the spinal cord, which is often sec-ondary to Chiari malformation (CMI), t......

CMV as a factor in the development of Alzheimer's disease?

期刊: MEDICAL HYPOTHESES, 2023; 178 ()

Cytomegalovirus (CMV) infection has been associated with poorer cognitive abilities, and there has recently been an association of T cell receptor alp......

Developmental stuttering may be caused by insufficient processing of auditory feedback

期刊: MEDICAL HYPOTHESES, 2023; 180 ()

Developmental stuttering has been scientifically researched for about a hundred years, but the cause is still unknown. Here, a comprehensive causal hy......

Hippocampal dysfunction underlies delusions of control in schizophrenia

期刊: MEDICAL HYPOTHESES, 2023; 173 ()

Current treatments for delusions in schizophrenia are only partly effective, and a better understanding of delusional pathophysiology would lead to ne......

Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion

期刊: MEDICAL HYPOTHESES, 2023; 178 ()

Meniscal extrusion treatment is a key focus area for research and clinical study of degenerative knee pathology. The contact forces between the menisc......

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