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Unexplained Hyperthyroglobulinemia in Differentiated Thyroid Cancer Patients as an Indication for Radioiodine Adjuvant Therapy: A Prospective Multicenter Study

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (1)

The management for totally thyroidectomized differentiated thyroid cancer (TT-DTC) patients with unexplained hyperthyroglobulinemia remains indetermin......

Predicting Gemcitabine Delivery by F-18-FAC PET in Murine Models of Pancreatic Cancer

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (2)

F-18-FAC (2'-deoxy-2'-F-18-fluoro-beta-D-arabinofuranosylcytosine) has close structural similarity to gemcitabine and thus offers the potential to ima......

First-in-Humans Study of Ga-68-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (4)

Sialic acid-binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A Ga-68-labeled peptide of Siglec-9, Ga-68-DOTA......

Intraprostatic Tumor Segmentation on PSMA PET Images in Patients with Primary Prostate Cancer with a Convolutional Neural Network

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (6)

Accurate delineation of the intraprostatic gross tumor volume (GTV) is a prerequisite for treatment approaches in patients with primary prostate cance......

Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (3)

Resection of soft-tissue sarcoma (STS) is accompanied by a high rate of tumor-positive surgical margins (14%-34%), which potentially lead to decreased......

Noninvasive Evaluation of CD20 Expression Using Cu-64-Labeled F(ab ')(2) Fragments of Obinutuzumab in Lymphoma

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (3)

CD20-overexpressed non-Hodgkin lymphoma typically indicates progressive malignancy. Obinutuzumab is a next-generation Food and Drug Administration-app......

Fibroblast Activation Protein-Targeted PET/CT with Ga-68-FAPI for Imaging IgG4-Related Disease: Comparison to F-18-FDG PET/CT

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (2)

IgG4-related disease (RD) is characterized by lymphoplasmacytic infiltration enriched in IgG4-positive plasma cells and variable degrees of fibrosis w......

Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (6)

The world's first total-body PET scanner with an axial field of view (AFOV) of 194 cm is now in clinical and research use at our institution. The uEXP......

Peptide Receptor Radionuclide Therapy of Late-Stage Neuroendocrine Tumor Patients with Multiple Cycles of Lu-177-DOTA-EB-TATE

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (3)

This study aimed to evaluate the safety and efficacy of multiple cycles of Lu-177-DOTA-Evans blue (EB)-TATE peptide receptor radionuclide therapy (PRR......

A Phase 1 and Biodistribution Study of ABT-806i, an In-111-Radiolabeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806

期刊: JOURNAL OF NUCLEAR MEDICINE, 2021; 62 (6)

ABT-806 is a tumor-specific antibody targeting the epidermal growth factor receptor (EGFR). This study assessed safety, biodistribution, and pharmacok......

Total-Body Dynamic Reconstruction and Parametric Imaging on the uEXPLORER

期刊: JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (2)

The world's first 194-cm-long total-body PET/CT scanner (uEXPLORER) has been built by the EXPLORER Consortium to offer a transformative platform for h......

Multimodal F-18-AV-1451 and MRI Findings in Nonfluent Variant of Primary Progressive Aphasia: Possible Insights on Nodal Propagation of Tau Protein Across the Syntactic Network

期刊: JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (2)

Although abnormally folded tau protein has been found to self-propagate from neuron to connected neuron, similar propagation through human brain netwo......

Recovery of Decreased Metabotropic Glutamate Receptor 5 Availability in Abstinent Alcohol-Dependent Patients

期刊: JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (2)

Animal models of alcohol dependence and relapse demonstrate an important role of the glutamatergic system, in particular, cerebral metabotropic glutam......

Prospective Comparison of PET Imaging with PSMA-Targeted F-18-DCFPyL Versus (NaF)-F-18 for Bone Lesion Detection in Patients with Metastatic Prostate Cancer

期刊: JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (2)

Bone metastases in prostate cancer (PCa) have important prognostic significance, and imaging modalities used for PCa staging should have high sensitiv......

The Genetic Duet of BRAF V600E and TERT Promoter Mutations Robustly Predicts Loss of Radioiodine Avidity in Recurrent Papillary Thyroid Cancer

期刊: JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (2)

BRAF V600E and TERT promoter mutations, particularly their genetic duet, are well known to be associated with poor clinical outcomes of papillary thyr......

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